66211-46-9

Basic information

• Product Name: (R)-3-Amino-1,2-propanediol
• Synonyms: (2S)-3-AMINOPROPANE-1,2-DIOL;1,2-PROPANEDIOL, 3-AMINO-, (2R)-;1,2-PROPANEDIOL, 3-AMINO-, (2S)-;1,2-PROPANEDIOL, 3-AMINO, (R);1,2-PROPANEDIOL, 3-AMINO, (S);(R)-(+)-3-AMINO-1,2-PROPANDIOL;(R)-(+)-3-AMINO-1,2-PROPANEDIOL;(R)-3-AMINO-1,2-PROPANEDIOL
• CAS NO: 66211-46-9
• Molecular Formula: C₃H₉NO₂
• Molecular Weight: 91.11
• Product Categories: chiral;CHIRAL COMPOUNDS;Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry;Amino Alcohols;Chiral Building Blocks;Organic Building Blocks
• Mol File: 66211-46-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 54-56°C
• Boiling Point: 117-119 °C0.4 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: white to light yellow crystal powder
• Density: 1.175 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00116mmHg at 25°C
• Refractive Index: n20/D 1.483(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 12.11±0.35(Predicted)
• BRN: 4290608
• CAS DataBase Reference: (R)-3-Amino-1,2-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Amino-1,2-propanediol(66211-46-9)
• EPA Substance Registry System: (R)-3-Amino-1,2-propanediol(66211-46-9)

Safety Data

• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3259 8/PG 2
• WGK Germany: 3
• F: 10-34
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 66211-46-9(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C3H9NO2/c4-1-3(6)2-5/h3,5-6H,1-2,4H2/t3-/m1/s1

Upstream product

• 616-30-8 3-Amino-1,2-propanediol 
• 910655-43-5 ethyl (2R,1'R)-2-acetyloxy-3-(1'-phenylethyl)aminopropionate 
• 22195-47-7 4-aminomethyl-2,2-dimethyl[1,3]dioxolane 
• 60456-23-7 (S)-oxiranemethanol 
• 122697-84-1 (2R,5R)-2-(tert-Butyl)-5-(hydroxymethyl)-1,3-oxazolidin-3-carbonsaeure-methylester 
• 131321-84-1 (R)-1-azido-2,3-dihydroxypropane 

Downstream Products

• 908256-15-5 7-((R)-2,3-hydroxypropylamino)-3-(2-trifluoromethoxyphenyl)-2H-isoquinolin-1-one 
• 352524-57-3 (R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)oxazolidin-2-one 
• 1260088-79-6 (R)-1-(4-bromophenyl)-3-(2,3-dihydroxypropyl)urea 
• 1229937-22-7 (R)-3-(4,5-bis(benzyloxy)pyridin-2-yl)-4-(2,3-dihydroxypropyl)-1H-1,2,4-triazol-5(4H)-one 
• 1421687-06-0 C₂₁H₂₈N₄O₆ 
• 1613622-88-0 (R)-5-(3-chlorophenyl)-6-(2,3-dihydroxypropyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione 
• 6217-54-5 docosahexaenoic acid 
• 10417-94-4 all cis-5,8,11,14,17-eicosapentaenoic acid 
• 2234-74-4 docosa-7Z,10Z,13Z,16Z,19Z-pentaenoic acid 

Relevant articles and documents

HIV INTEGRASE INHIBITORS

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Synthesis and properties of crosslinked chiral nanoparticles via RAFT miniemulsion polymerization

Crosslinked chiral nanoparticles were successfully synthesized via reversible addition-fragmentation chain transfer (RAFT) miniemulsion polymerization of 6-O-p-vinylbenzyl-1,2:3,4di-O-isopropylidene-D-galactopyranose (VBPG) using linear poly(VBPG) as the macro-RAFT agent. The polymerization of VBPG in the absence of crosslinker was first studied and the kinetic results showed that the molecular weights of the obtained poly(VBPG) increased linearly with the monomer conversion and was in good consistency with the corresponding theoretical ones while there remained a relative narrow polydisperslty. The effect of the amount of crosslinker, divlnylbenzene, on the nanoparticle size and chiral separation properties of the obtained nanoparticles were investigated in detail using four racemates ±-3-Amino-1,2propanediol, D,L-arablnose, D,L-tartaric acid, and D,L-mandelic acid.

Efficient Pathways to (R)- and (S)-5-Hydroxymethyl-2-oxazolidinone and some Derivatives

2-Oxazolidinones are a very interesting class of compounds due to their various pharmacological effects.Two new syntheses of enantiomerically pure (R)- and (S)-5-hydroxymethyl-2-oxazolidinone have been developed starting with D-mannitol, L-ascorbic acid and (R)- or (S)-malic acid. (R)- and (S)-5-hydroxymethyl-2-oxazolidinone have been used to synthesize some new homochiral 2-oxazolidinone derivatives.