616-30-8Relevant articles and documents
COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED FROM A DIASTEREOISOMERICALLY ENRICHED PCTA AND PREPARATION AND PURIFICATION PROCESS
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Paragraph 0027-0028, (2021/12/03)
The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
PROCESS FOR THE PREPARATION OF A 3-AMINO-1,2-PROPANDIOL AND DERIVATIVES THEREOF
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Page/Page column 9; 10, (2019/02/13)
Process for the preparation of a compound of formula (I) with R1 and R2 independently from each other representing hydrogen or a C1-to C10 alkyl group by a two-step process wherein the first step is an amination of the compound of formula (II) with an amino compound HNR1 R2 in the presence of hydrogen and resulting in the compound of formula (III) and the second step is a ring-cleaving of the compound of formula (III) giving the compound of formula (I).
A process for the preparation of amino-glycerol
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Paragraph 0017; 0023-0025, (2017/02/09)
The invention belongs to the chemical field, particularly relates to a production and synthesis technology of a medical intermediate, and provides a preparation method of 3-amino-1,2-propanediol mainly aiming at a 3-amino-1,2-propanediol product. The preparation method of 3-amino-1,2-propanediol adopts epichlorohydrin and ammonia water as the main raw materials, a two-component catalyst is used in a hydrolysis reaction process and an ammoniation reaction process respectively, the reaction temperature in earlier period and later period in a hydrolysis reaction kettle is increased in a segmented manner, the reaction selectivity is improved, side effects are reduced, the reaction rate is increased, the reaction time is shortened, and energy consumption is reduced. The specific operation flow of the preparation method comprises the hydrolysis reaction, neutralization, distillation, ammoniation reaction, filtering, distillation, centrifugation and rectification. Meanwhile, the catalyst can be recycled and the cost can be saved, and the preparation method further has the advantages of high safety, stable product quality, high purity and the like.