6622-60-2

Basic information

• Product Name: (2E)-1-(2-hydroxy-4-methoxyphenyl)-3-thiophen-2-ylprop-2-en-1-one
• Synonyms: (2E)-1-(2-Hydroxy-4-methoxyphenyl)-3-(2-thienyl)prop-2-en-1-one; 2-Propen-1-one, 1-(2-hydroxy-4-methoxyphenyl)-3-(2-thienyl)-, (2E)-
• CAS NO: 6622-60-2
• Molecular Formula: C₁₄H₁₂O₃S
• Molecular Weight: 260.3083
• Mol File: 6622-60-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 465.9°C at 760 mmHg
• Flash Point: 235.6°C
• Density: 1.29g/cm³
• Vapor Pressure: 2.65E-09mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: (2E)-1-(2-hydroxy-4-methoxyphenyl)-3-thiophen-2-ylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(2-hydroxy-4-methoxyphenyl)-3-thiophen-2-ylprop-2-en-1-one(6622-60-2)
• EPA Substance Registry System: (2E)-1-(2-hydroxy-4-methoxyphenyl)-3-thiophen-2-ylprop-2-en-1-one(6622-60-2)

Safety Data

• Hazardous Substances Data: 6622-60-2(Hazardous Substances Data)

Usage

General Description

The chemical (2E)-1-(2-hydroxy-4-methoxyphenyl)-3-thiophen-2-ylprop-2-en-1-one is an organic compound with the molecular formula C13H12O3S. It is a yellowish powder with a molecular weight of 248.3 g/mol. (2E)-1-(2-hydroxy-4-methoxyphenyl)-3-thiophen-2-ylprop-2-en-1-one contains a thiophene ring and a propenone group, and it is commonly used in pharmaceutical and organic synthesis as a building block for more complex compounds. Additionally, it exhibits antioxidant and antimicrobial properties, making it potentially useful in various industrial and medical applications. However, as with all chemicals, it should be handled and used with care to minimize potential risks to health and the environment.

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Relevant articles and documents

Thallium(III) p-tosylate-mediated oxidative [1,2] rearrangement of 2-naphthyl and 2-heteroarylchromanones

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Extended Aromatic and Heteroaromatic Ring Systems in the Chalcone-Flavanone Molecular Switch Scaffold

Previous work on the o-hydroxychalcone/flavanone molecular switching scaffold showed that simple substitutions alter the pH range in which rapid interconversion occurs. Herein, more impactful structural modifications were performed via alteration of the characteristic phenyl rings to alternative aromatic systems. It was determined that the scaffold was still viable after these changes and that the range of accessible midpoint pH values was markedly increased. To further explore the switch's scope, scaffolds able to have multiple switching events were also investigated.

The Preparation of Flavones and their Derivatives. Part I. Flavones and 4-Thioflavones.

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