66234-45-5

Upstream product

• 53449-14-2 7-chloro-6-nitro-4(3H)-quinazolinone 
• 74-88-4 methyl iodide 

Downstream Products

• 66234-57-9 7-benzylamino-3-methyl-6-nitro-3H-quinazolin-4-one 
• 81946-10-3 6-Amino-7-benzylamino-3-methyl-3H-quinazolin-4-one 
• 81946-12-5 6-Amino-3-methyl-7-(3-phenyl-propylamino)-3H-quinazolin-4-one 
• 81946-19-2 (3-Benzyl-7-methyl-8-oxo-7,8-dihydro-3H-imidazo[4,5-g]quinazolin-2-yl)-carbamic acid methyl ester 
• 81946-20-5 (3-Benzyl-7-methyl-8-oxo-7,8-dihydro-3H-imidazo[4,5-g]quinazolin-2-yl)-carbamic acid ethyl ester 
• 81946-21-6 [7-Methyl-8-oxo-3-(3-phenyl-propyl)-7,8-dihydro-3H-imidazo[4,5-g]quinazolin-2-yl]-carbamic acid ethyl ester 
• 81946-06-7 3-Methyl-6-nitro-7-(3-phenyl-propylamino)-3H-quinazolin-4-one 
• 81946-05-6 7-(2-Hydroxy-ethylamino)-3-methyl-6-nitro-3H-quinazolin-4-one 
• 66234-56-8 3-Methyl-6-nitro-7-morpholino-chinazolin-4-on 

Relevant academic research and scientific papers

A near-infrared fluorescent probe based on a novel rectilinearly π-extended rhodamine derivative and its applications

We designed and synthesized a novel near-infrared (NIR) mitochondria-Targeted fluorescent probe RQNA for the specific detection of mitochondrial Cu2+ because mitochondria are important reservoirs of intracellular copper. For the preparation of this probe, a novel π-extended fluorescent xanthene dye RQN was firstly synthesized via an intramolecular nucleophilic substitution of aromatic hydrogen (SNArH) strategy. Then, probe RQNA was prepared by the reaction of RQN and hydrazine hydrate, followed by treatment with acetone. RQNA exhibited selectivity, sensitivity (22 nM), and fast response time (20 s) for the detection of Cu2+via a specific Cu2+-Triggered ring-opening and hydrolysis cascade reaction. RQNA is cell-membrane permeable and mitochondria-Targetable, and can be used for monitoring mitochondrial Cu2+ in living cells.

Large Stokes shift dark red fluorescent probe RQNA for detecting copper ions, and preparation method and application thereof

The invention provides a large Stokes shift dark red fluorescent probe RQNA for detecting copper ions, and a preparation method and an application thereof. The preparation method comprises the following steps: adding hydrazine hydrate into a methanol solution of a dye RQN, performing a reaction, removing the solvent, dissolving the obtained reaction product in acetone, and performing a reaction toobtain the solid probe RQNA. The probe is simple to synthesize and has mild reaction conditions. The prepared probe has a high selectivity and a high sensitivity, can react with copper ions in a widepH range, has a short response time, and causes remarkable change of a dark red fluorescence emission spectrum to realize specific detection of the copper ions. Cell imaging experiments show that theprobe has a good cell membrane permeability, a low cytotoxicity and a mitochondrial targeting positioning function, and successfully achieves fluorescence imaging detection of copper ions in human cervical cancer (HeLa) cells.

Possible Anthelmintic Agents: Syntheses of Various Imidazoquinazolinone Carbamates

Two of the three possible imidazoquinazolinone-2-carbamates representing angular and linear heterocyclic systems, have been synthesised and evaluated for their anthelmintic activity.During the course of the synthesis of ethyl or methyl 7-alkylimidazoquinazolin-8-one-2-carbamate, it is observed that the reaction of 3-alkyl-7-chloro-6-nitroquinazolin-4-ones with butanol saturated with aq.NH3, furnishes a number of ring-opened products which have been characterised on the basis of elemental analyses, IR, PMR and mass spectral data.The same reaction when carried out with dry NH3, furnishes the desired amino-nitro derivatives.UV and IR spectra of the linear and angular imidazoquinazolinones have also been compared.