53449-14-2

Basic information

• Product Name: 6-Nitro-7-Chloro-4-HydroxyQuinazoline
• Synonyms: 6-Nitro-7-Chloro-4-HydroxyQuinazoline;7-CHLORO 6-NITRO QUINAZOLINE 4-OL;7-Chloro-6-nitro-4-hydroxyquinazoline;6-Nitro-7-chloro-3,4-dihydroquinazolin-4-one;7-Chloro-1,4-dihydro-6-nitro-4-oxoquinazoline;7-Chloro-6-nitroquinazolin-4(1H)-one;7-Chloro-6-nitro-4-quinazolinol;7-Chloro-6-nitro-3H-quinazolin-4-one
• CAS NO: 53449-14-2
• Molecular Formula: C₈H₄ClN₃O₃
• Molecular Weight: 225.59
• EINECS: 1312995-182-4
• Product Categories: Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;New Products for Chemical Synthesis;Quinazolines
• Mol File: 53449-14-2.mol
• Article Data: 22

Chemical Properties

• Melting Point: 314-319℃
• Boiling Point: 457.671 °C at 760 mmHg
• Flash Point: 230.591 °C
• Appearance: /
• Density: 1.706 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.756
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: slightly sol. in Dimethylformamide
• PKA: -2.49±0.20(Predicted)
• CAS DataBase Reference: 6-Nitro-7-Chloro-4-HydroxyQuinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Nitro-7-Chloro-4-HydroxyQuinazoline(53449-14-2)
• EPA Substance Registry System: 6-Nitro-7-Chloro-4-HydroxyQuinazoline(53449-14-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 53449-14-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow or light yellow powder

InChI:InChI=1/C8H4ClN3O3/c9-5-2-6-4(1-7(5)12(14)15)8(13)11-3-10-6/h1-3H,(H,10,11,13)

Upstream product

• 31374-18-2 7-chloro-3,4-dihydroquinazolin-4-one 
• 5900-59-4 2-amino-4-chlorobenzamide 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 74-11-3 para-chlorobenzoic acid 
• 100948-85-4 4-chloro-5-nitroanthranilic acid 
• 149-73-5 trimethyl orthoformate 
• 31374-18-2 7-chloroquinazolin-4(1H)-one 
• 7664-93-9 sulfuric acid 

Downstream Products

• 105664-93-5 6-nitro-7(methylamino)quinazolin-4(3H)-one 
• 53449-26-6 7-benzylamino-6-nitro-3H-quinazolin-4-one 
• 16292-86-7 2-hydroxy-4-amino-1-nitrobenzene 
• 5131-58-8 2,4-diaminonitrobenzene 
• 81946-23-8 2,4-diamino-5-nitro-benzoic acid 
• 53449-16-4 7-amino-6-nitroquinazolin-4(3H)-one 
• 1012057-47-4 7-methoxy-6-nitroquinazolin-4(3H)-one 
• 162012-71-7 4,7-dichloro-6-nitro-quinazoline 
• 81946-01-2 7-Chloro-3-heptyl-6-nitro-3H-quinazolin-4-one 
• 168761-50-0 7-(ethylamino)-6-nitroquinazoline-4(3H)-one 
• 1012057-58-7 7-(2-methoxyethoxy)-6-nitro-4(3H)-quinazolinone 
• 55496-69-0 4-chloro-7-methoxy-6-nitroquinazoline 
• 171745-11-2 (3-Bromo-phenyl)-(7-chloro-6-nitro-quinazolin-4-yl)-amine 
• 171745-10-1 N-(3-bromophenyl)-7-methoxy-6-nitroquinazoline-4-amine 

Relevant articles and documents

Synthesis of alkylamino quinazolines and anti-tumor activity thereof

The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, or ester, or prodrug thereof. The invention further provides a compound represented by the formula (I) or a pharmaceutically acceptable salt or ester, or a synthetic method of the prodrug and an application of the compound in preparation of a medicament for treating tumors.

Tetrahydroisoquinoline derivatives preparation and application of (by machine translation)

The invention mainly relates to a series of containing tetrahydroisoquinoline structure the synthesis of the compounds and in the medical field of application. Specifically, the invention relates to a series of tetrahydroisoquinoline structure compound, it can inhibit the polymerization of A β, antagonizing A β O in combination and in nerve cells caused by the cytotoxic, therapeutic or improve AD has application prospect. (by machine translation)

Artemisin derivative and its preparation and use

Provided are artemisinin derivatives of formula (I) or pharmaceutically acceptable salts thereof, or enantiomers, diastereomers, and racemic bodies thereof, and a pharmaceutical composition of the compounds, the preparation process and uses thereof. Artemisinin derivatives of formula (I) have excellent effects in the treatment of tumours.