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66246-88-6

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  • Agriculture Pesticide Fungicide Penconazole CAS 66246-88-6

    Cas No: 66246-88-6

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  • 1 Metric Ton

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66246-88-6 Usage

Uses

Different sources of media describe the Uses of 66246-88-6 differently. You can refer to the following data:
1. Penconazole is an conazole based fungicide that works by inhibiting cell membrane ergosterol biosynthesis, thus stopping the development of fungi.
2. Penconazole is used for the control of powdery mildew, pome fruit scab and other pathogenic Ascomycetes, Basidiomycetes and Deuteromycetes on vines, cucurbits, pome fruit, stone fruit, ornamentals, hops, tobacco and vegetables.

Agricultural Uses

Fungicide: Penconazole is a systemic fungicide used to control powdery mildew. It is used on apples and grapes and other fruits, hops, tobacco, ornamentals and on vegetables. Not currently registered in the U.S. Reported to be used in most European countries. Currently, there are more than 30 global suppliers.

Trade name

AWARD?; CGA-71818?; ONMEX?; TOPAS?; TOPAS-C?; TOPAS-MZ?; TOPAZ?; TOPAZE?; TOPAZE-C?; TOPENCO 100EC?

Safety Profile

Moderately toxic by ingestion and skin contact. When heated to decomposition it emits toxic vapors of NOx and Clí.

Metabolic pathway

Penconazole is metabolised in plants by hydroxylation of the propyl side chain and conjugation or metabolism to triazolylalanine and triazolylacetic acid. It is quite persistent in soils but degradation by sunlight requires only a few days. It is eliminated rapidly from mammals.

Degradation

Penconazole (1) is stable to hydrolysis at pH 1-13 and at temperatures up to 350 °C. It is degraded in sunlight with a DT50 of 4 days in natural sunlight. Its photochemical reactions have been studied. On irradiation with light of wavelengths greater than 280 nm (high-pressure mercury lamp with filter), the major reaction was the formation of a cyclised product (2) (Scheme 1). Irradiation under the same conditions in isopropanol gave mainly 2 and 3 (a dechlorinated product). After 8 hours, yields were 29.8% of 2 and 12.3% of 3 respectively. The product 3 alone photodegraded only slowly but 2 was completely photolysed within 3 hours to further products, indicating its role as an intermediate in the photolytic pathways (Schwack and Hartmann, 1992, 1994). In the presence of isopropanol, photodehalogenation of 3 to 4 competed with substitution of a solvent molecule to give a low yield (

Check Digit Verification of cas no

The CAS Registry Mumber 66246-88-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,2,4 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66246-88:
(7*6)+(6*6)+(5*2)+(4*4)+(3*6)+(2*8)+(1*8)=146
146 % 10 = 6
So 66246-88-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H11NO2/c1-5(2)6-8-4-3-7/h7H,3-4H2,1-2H3

66246-88-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name penconazole

1.2 Other means of identification

Product number -
Other names topaze

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66246-88-6 SDS

66246-88-6Synthetic route

1-(1H-1,2,4-triazol-1-yl)-2-(2,4-dichlorophenyl)-1-penten

1-(1H-1,2,4-triazol-1-yl)-2-(2,4-dichlorophenyl)-1-penten

penconazole
66246-88-6

penconazole

Conditions
ConditionsYield
rhodium contaminated with carbon; platinumoxide; rhodiumoxide In tetrahydrofuran at 20℃; under 750.06 Torr; for 5.5h;71.4%
1-[2-(2,4-dichlorophenyl)-pentyl]-1,2-diformylhydrazine

1-[2-(2,4-dichlorophenyl)-pentyl]-1,2-diformylhydrazine

penconazole
66246-88-6

penconazole

Conditions
ConditionsYield
In formamide
penconazole
66246-88-6

penconazole

2-[2-(2,4-dichlorophenyl)-pentyl]-2,4-dihydro-[1,2,4]triazole-3-thione
187670-56-0

2-[2-(2,4-dichlorophenyl)-pentyl]-2,4-dihydro-[1,2,4]triazole-3-thione

Conditions
ConditionsYield
Stage #1: penconazole With isopropylmagnesium chloride In tetrahydrofuran at 40℃; for 1.5h;
Stage #2: With sulfur In tetrahydrofuran at 0℃; for 1h;
Stage #3: With hydrogenchloride; water In tetrahydrofuran
60%
penconazole
66246-88-6

penconazole

A

C13H13Cl2N3O

C13H13Cl2N3O

B

C13H13Cl2N3O

C13H13Cl2N3O

Conditions
ConditionsYield
With oxygen; tetramethylammonium tetrafluoroborate; C5H13N2O(1+)*BF4(1-); sodium hydrogencarbonate In water; acetonitrile Reagent/catalyst; Electrochemical reaction;A 19%
B 7%
1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

hydrogen sulfide
7783-06-4

hydrogen sulfide

penconazole
66246-88-6

penconazole

2-(2,4-dichloro-phenyl)-1-(5-mercapto-1,2,4-triazol-1-yl)-pentane

2-(2,4-dichloro-phenyl)-1-(5-mercapto-1,2,4-triazol-1-yl)-pentane

hydrogen sulfide
7783-06-4

hydrogen sulfide

penconazole
66246-88-6

penconazole

2-(2,4-dichloro-phenyl)-1-(5-mercapto-1,2,4-triazol-1-yl)-pentane

2-(2,4-dichloro-phenyl)-1-(5-mercapto-1,2,4-triazol-1-yl)-pentane

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one
With 1-methyl-pyrrolidin-2-one
With 1-methyl-pyrrolidin-2-one
With 1-methyl-pyrrolidin-2-one
penconazole
66246-88-6

penconazole

(-)-penconazole

(-)-penconazole

(+)-penconazole

(+)-penconazole

Conditions
ConditionsYield
With chiralpak IC column In hexane; isopropyl alcohol at 20℃; Thermodynamic data; Solvent; Temperature; Resolution of racemate; enantioselective reaction;

66246-88-6Related news

Sorption of Penconazole (cas 66246-88-6) applied as a commercial water–oil emulsion in soils devoted to vineyards07/21/2019

The objective of this work was to assess the effect of surfactants and oils of a commercial formulation on the potential mobility of penconazole in agricultural soils that have been subjected to a high rate of application of agricultural chemicals. Soil–water partition tests on a commercial wat...detailed

Improving tolerance against drought in canola by Penconazole (cas 66246-88-6) and calcium07/19/2019

Drought stress is one of the most important environmental factors that limit plant growth. Canola is an important agricultural crop grown primarily for its edible oil. In this study, penconazole (PEN), a triazole growth regulator, and calcium (Ca2+), a secondary messenger, were used to analyses ...detailed

Effects of two different organic amendments addition to soil on sorption–desorption, leaching, bioavailability of Penconazole (cas 66246-88-6) and the growth of wheat (Triticum aestivum L.)07/18/2019

This study investigated the effects of sugarcane bagasse compost (SBC) and chicken manure compost (CMC) on the sorption–desorption, leaching and bioavailability of the fungicide penconazole in soil in a laboratory setting. The autoclave-treated SBC or CMC was applied at 2.5% and 5.0% (w/w). Res...detailed

Simultaneous determination of 4-tert-octylphenol, chlorpyrifos-ethyl and Penconazole (cas 66246-88-6) by GC–MS after sensitive and selective preconcentration with stearic acid coated magnetic nanoparticles07/17/2019

Endocrine disruptive compounds are widely used and well-known chemicals that could alter some vital processes taking place in living organisms. These chemicals might cause serious health disorders such as different types of cancer, sexual anorexia and mood disorders. In this study, combination o...detailed

Long-term occupational and environmental exposure to Penconazole (cas 66246-88-6) and tebuconazole by hair biomonitoring07/15/2019

Penconazole (PEN) and tebuconazole (TEB) are fungicides widely used in vineyards. The aim of this the study was to assess the suitability of hair to assess long-term exposure to PEN and TEB.Hair samples of agricultural workers exposed to PEN (AW-PEN, 18 subjects) or TEB (AW-TEB, 2 subjects) duri...detailed

Assessment of Penconazole (cas 66246-88-6) exposure in winegrowers using urinary biomarkers07/14/2019

Penconazole (PEN) is a fungicide used in agriculture. The aim of this work was to evaluate the exposure to PEN in vineyard workers focusing on urinary biomarkers.Twenty-two agricultural workers were involved in the study; they were investigated during PEN applications and re-entry work, performe...detailed

Penconazole (cas 66246-88-6) alters redox status, cholinergic function and lung’s histoarchitecture of adult rats: Reversal effect of vitamin E07/13/2019

The present study pertains to the possible adverse effects of penconazole exposure on the lung of adult rats, and to the potential ability of vitamin E (Vit E) in mitigating the toxicity induced by this fungicide. Male Wistar rats were divided into four groups of six animals each: Group I (Contr...detailed

Application and enantioselective residue determination of chiral pesticide Penconazole (cas 66246-88-6) in grape, tea, aquatic vegetables and soil by ultra performance liquid chromatography-tandem mass spectrometry07/12/2019

Penconazole is a typical triazole fungicide with wide use on fruits, vegetables, and tea plants to control powdery mildew. In the present study, an efficient graphite carbon black solid phase extraction (GCB-SPE) purification combined with chiral ultra performance liquid chromatography tandem ma...detailed

Developmental toxicity of Penconazole (cas 66246-88-6) in Zebrfish (Danio rerio) embryos07/11/2019

Penconazole is a widely used fungicide that is toxic to a variety of organisms including fish. In the present study, we investigated the developmental toxicity of penconazole on zebrafish embryos by exposing to different concentrations of penconazole (0.8, 1.6 and 2.4 mg/L) from 4-h post-fertili...detailed

66246-88-6Relevant articles and documents

Synergistic Fungidical Active Substance Combinations

-

, (2008/12/04)

The present invention relates to novel active substance combinations which contain spiroxamine, which is known, a known azole and a known carboxamide and which are very suitable for controlling undesired phytopathogenic fungi.

Pyrazolyl benzyl ether derivatives containing a fluoromethoxyimino group and use thereof as pesticides

-

, (2008/06/13)

The invention relates to novel pyrazolyl benzyl ethers, to a plurality of processes for their preparation and to their use for controlling harmful organisms.

Use of aminoisothiazoles as microbicides

-

, (2008/06/13)

PCT No. PCT/EP97/06854 Sec. 371 Date Jun. 16, 1999 Sec. 102(e) Date Jun. 16, 1999 PCT Filed Dec. 9, 1997 PCT Pub. No. WO98/27816 PCT Pub. Date Jul. 2, 1998Aminoisothiazoles of the formula I, where R is hydrogen or C1-C4 alkyl and X is halogen, NO2, CN or SCN, and metal complexes and acid addition salts thereof are used as microbicides for protecting industrial materials from being attacked and destroyed by microorganisms.

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