6625-88-3

Usage

Uses

Used in Pharmaceutical Industry:
[3-(hydroxymethyl)phenoxy]acetic acid is used as an intermediate for the synthesis of various pharmaceuticals, leveraging its ability to function as a building block in the creation of other organic compounds. Its presence in the synthesis process contributes to the development of new drugs and medicines.
Used in Agrochemical Industry:
In the agrochemical sector, [3-(hydroxymethyl)phenoxy]acetic acid is utilized as an intermediate in the production of various agrochemicals. Its role in this industry is crucial for the synthesis of compounds that help in enhancing crop protection and yield.
Used in Fine Chemicals Industry:
[3-(hydroxymethyl)phenoxy]acetic acid is also employed as an intermediate in the synthesis of fine chemicals, which are high-purity, specialty chemicals used in various applications such as fragrances, flavors, and other high-value products.
As with any chemical, it is essential to follow proper handling and safety precautions when working with [3-(hydroxymethyl)phenoxy]acetic acid to ensure the safety of both individuals and the environment.

Upstream product

• 93306-78-6 3-hydroxymethyl-1-ethoxycarbonylmethoxybenzene 
• 37748-09-7 2-(3-formylphenoxy)acetic acid 

Downstream Products

• 820220-95-9 KNI-10124 
• 93306-78-6 3-hydroxymethyl-1-ethoxycarbonylmethoxybenzene 

Relevant academic research and scientific papers

Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin

Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-dimethylthioproline scaffold to exhibit potent inhibitory activities against Plm II. Their activities against Plasmodium falciparum in the infected erythrocyte assay were largely different from those against the target enzyme. To improve the antimalarial activity of peptidomimetic Plm inhibitors, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, we identified alkylamino compounds such as 44 (KNI-10283) and 47 (KNI-10538) with more than 15-fold enhanced antimalarial activity, to the sub-micromolar level, maintaining their potent Plm II inhibitory activity and low cytotoxicity. These results suggest that auxiliary substituents on a specific basic group contribute to deliver the inhibitors to the target Plm.

[(4-phenyl-1,3-dioxan-cis-5-yl)alkyl]phenylalkanoic acid derivatives

The invention concerns novel [(4-phenyl-1,3-dioxan-cis-5-yl)alkyl]phenylalkanoic acids of the formula I wherein Ra and Rb are a variety of substituents including alkyl, alkenyl, halogenoalkyl, phenyl and benzyl, or together form polymethylene; Rc is hydro