66254-55-5

Basic information

• Product Name: (1S)-(-)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID
• Synonyms: (1S)-(-)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID;L-1-AMINO-2-METHYLPROPYLPHOSPHONIC ACID;H-VALP-(OH)2;H-S-VAL(P)-OH;H-AMEPROPP(O)-(OH)2;(S)-1-PHOSPHONO-2-METHYL-PROPYLAMINE;(S)-1-AMINO-2-METHYLPROPHOSPHATE ACID;(S)-(-)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID
• CAS NO: 66254-55-5
• Molecular Formula: C4H12NO3P
• Molecular Weight: 153.12
• Mol File: 66254-55-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 272-277 °C(lit.)
• Boiling Point: 302.9°C at 760 mmHg
• Flash Point: 137°C
• Appearance: /
• Density: 1.295g/cm³
• Vapor Pressure: 0.000223mmHg at 25°C
• Refractive Index: 1.486
• PKA: 0.94±0.10(Predicted)
• CAS DataBase Reference: (1S)-(-)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-(-)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID(66254-55-5)
• EPA Substance Registry System: (1S)-(-)-(1-AMINO-2-METHYLPROPYL)PHOSPHONIC ACID(66254-55-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 66254-55-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C4H12NO3P/c1-3(2)4(5)9(6,7)8/h3-4H,5H2,1-2H3,(H2,6,7,8)/t4-/m0/s1

Upstream product

• 65576-83-2 (-)-1-amino-2-methylpropylphosphonous acid 
• 18108-24-2 (1-amino-2-methylpropyl)phosphonic acid 
• 88081-72-5 C₃₄H₃₂NO₁₀P 
• 134153-94-9 l-<1-(benzylamino)-2-methylpropyl>phosphonic acid 
• 101040-21-5 (+)-(S)-diethyl (1-amino-2-methylpropyl)phosphonate 
• 1795-31-9 tris(trimethylsilyl) phosphite 
• 78-84-2 isobutyraldehyde 

Relevant articles and documents

Biocatalyzed kinetic resolution of racemic mixtures of chiral α-aminophosphonic acids

Several fungal species namely: Aspergillus niger, Aspergillus parasiticus, Penicillium funiculosum, Trigonopsis variabilis and two different strains of Fusarium oxysporum were tested toward racemic mixtures of following phosphonic acids: 1-amino-2-methylp

Enantioselective Synthesis of α-Amino Phosphonic Acids by an Application of Stereoselective Opening of Homochiral Dioxane Acetals with Triethyl Phosphite

Stereoselective opening of homochiral acetals (2a-c) with triethyl phosphite was applied to the enantioselective synthesis of phosphono alcohols (1a-c), which were succssefully converted to the α-amino phosphonic acid diethyl esters (6a-c).

133. Nucleophilic Additions to N-Glycosylnitrones. Part IV. Asymmetric Synthesis of N-Hydroxy-α-aminophosphonic and α-Aminophosphonic Acids

The addition of phosphite anions and of tris(trimethylsilyl)phosphite (P(OSiMe3)3) to N-glycosyl-C-aryl-nitrones was examined.While these nitrones proved inert towards the phosphite anions, they reacted with P(OSiMe3)3 under catalysis by Lewis acids.Thus,