66259-07-2

Upstream product

• 1719-58-0 Chlorodimethylvinylsilane 
• 586-76-5 4-Bromobenzoic acid 
• 221238-61-5 2-<4-(vinyldimethylsilyl)phenyl>-4,4-dimethyloxazoline 

Downstream Products

• 221238-73-9 dimethyl N-<(4-vinyldimethylsilyl)benzoyl>-L-glutamate 
• 1112416-26-8 C₂₆H₃₀N₂O₃SSi 
• 221238-95-5 dimethyl N-<4-<3-(2-pivaloylamino-4(3H)-oxo-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl)-1,1-dimethyl-1-silapropyl>benzoyl>-L-glutamate 

Relevant academic research and scientific papers

SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

The present invention relates to a novel class of Silicon derivatives. The Silicon compounds can be used to treat cancer. The Silicon compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation,

Potential silicon-containing antifolates

Novel silicon-containing folate derivatives were synthesized as potential inhibitors of folate-dependent enzymes in an attempt to develop more effective antitumor agents. A dimethylsilyl moiety was inserted into the sidechain of two known antifolates with the aim of improving passive transport properties and sidechain conformational flexibility. An efficient, convergent palladium-catalyzed coupling methodology was used to link known heterocycles to novel, highly functionalized vinyl and ethynyl silanes.