6628-69-9

Usage

Uses

Used in Chemical Synthesis:
4-(biphenyl-4-yloxy)aniline is used as a building block in the synthesis of organic compounds for various applications, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for the creation of a wide range of derivatives with diverse properties.
Used in Dye and Pigment Production:
In the dye and pigment industry, 4-(biphenyl-4-yloxy)aniline is used as a common intermediate. Its role in the production process is crucial for creating dyes and pigments with specific color characteristics and performance attributes, which are essential for various applications such as textiles, plastics, and printing inks.

Upstream product

• 92-69-3 4-Phenylphenol 
• 100-00-5 4-chlorobenzonitrile 
• 6641-61-8 4-(4-nitrophenoxy)-1,1'-biphenyl 

Downstream Products

• 1366234-36-7 C₂₂H₁₈N₄O 
• 1244974-78-4 C₄₇H₃₁F₆N₃O₈ 

Relevant academic research and scientific papers

Synthesis of a novel polyimide used as liquid crystal vertical alignment layers

A novel functional diamine containing a triphenylamine moiety and a biphenyl group, N,N-bis(4-aminophenyl)-4-(biphenyl)-4′-aminophenyl ether (N0), was successfully synthesized and characterized. A series of polyimides (PIs) and poly(amic acid)s (PAAs) were synthesized from cyclobutane-1,2,3,4-tetracarboxylic dianhydride (CBDA), 2,2′-bis(trifluoromethyl)-[1,1′-biphenyl]-4,4′-diamine (TFDB), 4-dodecyloxy-phenyl-4′,4″-diaminotriphenylamine (C12) and the newly synthesised diamine monomer (N0) through a conventional two-step procedure that included a ring-opening polyaddition to give polyamic acids, followed by thermal cyclodehydration. Pretilt angles of a liquid crystal (LC) cell fabricated with the PIs were measured, and the rubbing resistance of PIs containing different sidechain structures was investigated. PI1 with a rigid biphenyl side chain could induce LC parallel alignment after the rubbing process. Although PI3 containing a flexible alkyl side chain could induce LC vertical alignment before the rubbing process, it only induced LC parallel alignment after the rubbing process. However, PI2 containing both rigid biphenyl side chains and flexible alkyl side chains could induce LC vertical alignment before and after the rubbing process. A new method for improving the rubbing resistance of PIs and a generation mechanism of rubbing resistance have been proposed. In addition, all PI films showed high thermal stability and high transmittance in the wavelength range of 400-700 nm.

INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS

The present invention relates to new inhibitors of Notch signalling pathway and its use in the treatment and/or prevention of cancers.

A focused library of protein tyrosine phosphatase inhibitors

Protein tyrosine phosphatases such as PTP1B and YopH are potential targets for the development of therapeutic agents against a variety of pathological conditions including diabetes, obesity, and infection by the bacterium Yersinia pestis. A focused library of bidentate α-ketoacid-based inhibitors has been screened against several tyrosine phosphatases. Compound 2a has IC 50 values of 43 and 220 nM against YopH and PTP1B, respectively, and shows a 30-fold selectivity for PTP1B over the closely related phosphatase TCPTP.

Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors

The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA4-h inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the diphenyl ether moiety and diamine spacer is discussed. The resulting compounds such as 3l have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.