6629-36-3Relevant academic research and scientific papers
METHOD FOR THE ORGANOMETALLIC PRODUCTION OF ORGANIC INTERMEDIATE PRODUCTS COMPRISING CARBON-HETEROATOM BONDS ACHIEVED BY THE DEPROTONATION OF HETEROATOMS
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Page/Page column 14, (2008/06/13)
The invention relates to a method for binding heteroatom-carbon bonds. According to said method, a lithium compound (II) is first generated by reacting aliphatic or aromatic halogen compounds (I) with lithium metal, said compound is then used for the deprotonation of the compounds (III) or (V). The lithium salts of formulas (IV) or (VI) obtained by said deprotonation are subsequently reacted with suitable carbon electrophiles (equation I), said process binding the heteroatom-carbon bond and forming the products (VIII) or (VIII), (equation I).
Desulfonylation of amides using tributyltin hydride, samarium diiodide or zinc/titanium tetrachloride. A comparison of methods
Knowles, Haydn S.,Parsons, Andrew F.,Pettifer, Robert M.,Rickling, Stéphane
, p. 979 - 988 (2007/10/03)
Deprotection of N-sulfonylated amides can be achieved by reaction with Bu3SnH, SmI2 or TiCl4/Zn. All three methods gave good yields (typically >60%) when using N-benzoyl or related amides while the corresponding N~acetyl derivatives proved to be inert to deprotection under the same reaction conditions. The mechanistic implications of this are discussed. (C) 2000 Elsevier Science Ltd.
