6629-85-2

Usage

Uses

Used in Pharmaceutical Industry:
4-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one is used as a building block for the synthesis of pharmaceuticals due to its versatile chemical structure and biological activities, including antibacterial, antifungal, and antiviral properties.
Used in Agrochemical Industry:
4-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one is used as a building block for the synthesis of agrochemicals, contributing to the development of novel compounds with potential applications in agriculture.
Used in Polymer and Resin Production:
4-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one is used as a monomer in the production of polymers and resins, providing unique properties and functionalities to the resulting materials.
Used in Flavoring and Fragrance Industry:
4-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one is used in the preparation of flavoring agents and fragrances, offering a wide range of scents and tastes for various applications.
Used in Materials Science:
4-(hydroxymethyl)-4-methyl-1,3-oxazolidin-2-one has potential applications in the field of materials science, particularly in the development of advanced materials with unique properties and functionalities.

Upstream product

• 115-69-5 2-Amino-2-methylpropane-1,3-diol 
• 105-58-8 Diethyl carbonate 
• 106731-61-7 hexaethyl 1,1,1,10,10,10-decanehexacarboxylate 
• 74-88-4 methyl iodide 
• 616-38-6 carbonic acid dimethyl ester 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 98143-34-1 4-(chloromethyl)-4-methyloxazolidin-2-one 
• 1453082-71-7 4-(((tert-butyldiphenylsilanyl)oxy)methyl)-4-methyloxazolidin-2-one 

Relevant academic research and scientific papers

Two oxazolidinone derivatives

The structures of two substituted oxazolidinones, namely, 4-hydroxymethy 1-4-methyloxazolidin-2-one [C5H9NO3, (1)] and 4-ethyl-4-hydroxymethyloxazolidin2-one [C6H11NO3, (2)], are reported. Bond distances in the two structures are almost identical. The oxazolidinone rings both adopt envelope conformations; the fold in (1) is significantly larger than that in (2). There is no intramolecular hydrogen bonding in either structure and the intermolecular hydrogen-bonding schemes are very similar.

Organocatalytic valorisation of glycerol: Via a dual NHC-catalysed telescoped reaction

A general telescoped reaction for the NHC-catalysed carbonation and aerobic esterification of glycerol and 2-amino-2-methylpropane-1,3-diol has been developed. The reaction provides highly functionalised glycerol derivatives in good to excellent yields (up to 95%) using low catalyst loadings and ambient conditions.

RORγ MODULATORS

Described are RORγ modulators of the formula (I), or pharmaceutically acceptable salts thereof, wherein all substituents are defined herein. The invention includes stereoisomeric forms of the compounds of formula I, including stereoisomerically-pure, scalemic and racemic form, as well as tautomers thereof. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.

Antimicrobial Haloalkyl Heterocycle Compounds

This application describes compounds useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.

ANTIMICROBIAL OXAZOLIDINONE, HYDANTOIN AND IMIDAZOLIDINONE COMPOSITIONS

The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula (I): or pharmaceutically acceptable salts thereof, and associated compositions and methods of use as antimicrobial agents.

Synthesis of water soluble hyperbranched polyurethanes using selective activation of AB2 monomers

The synthesis of a novel water-soluble hyperbranched polyurethane is described. The synthetic strategy involves a new approach to hyperbranched polymerization through the selective activation of the A functionality of the unprotected of AB2 monomer. 1,1′-Carbonyl diimidazole is added at room temperature to an amino-diol monomer with the corresponding selective formation of an active carboxamide and no detectable reaction at the hydroxyl B functional groups. The active monomer self-condenses to form hyperbranched polyurethanes with measured degrees of branching equaling 0.6 and Ma up to 11 000 Da. A series of model reactions has been conducted to confirm the polymerization mechanism, and ideally branched model molecules have been used to assign the 15N NMR spectra of the hyperbranched polymers. Reaction conditions have been varied, and the factors affecting the polymerization are discussed.

Synthesis and characterization of two-directional cascade molecules and formation of aqueous gels

Numerous two-directional cascade molecules (arborols) have been prepared via a simple two-step procedure. These cascade molecules have been abbreviated as [m]-n-[m] arborols, where m is the number of hydroxyl moieties on the cascade spherical surface and n is the number of methylenes connecting the cascade spheres. Several of the arborols in the [9]-n-[9] and [6]-n-[6] series form thermally reversible aqueous gels; properties of these gels are discussed. An aggregation model is proposed for the gel-forming molecules; preliminary molecular modeling calculations and electron micrograph data support this model.

Method of moisturizing the skin with carbamide acid esters

Skin-care, skin-protection, and skin-cleaning agent compositions containing as a skin-moisturizing agent at least one substituted carbamide acid ester, said substituted carbamide acid ester having the formula STR1 wherein R1 is a member selecte