115-69-5

Basic information

• Product Name: 2-Amino-2-methyl-1,3-propanediol
• Synonyms: 1,1-Di(hydroxymethyl)ethylamine;1,3-Dihydroxy-2-methyl-2-propylamine;1,3-Propanediol, 2-amino-2-methyl-;2-amino-2-methyl-3-propanediol;2-Amino-2-methylpropan-1,3-diol;2-Amino-2-methylpropane-1,3-diol;2-Amino-2-methylpropanediol;3-Propanediol,2-amino-2-methyl-1
• CAS NO: 115-69-5
• Molecular Formula: C₄H₁₁NO₂
• Molecular Weight: 105.14
• EINECS: 204-100-7
• Product Categories: Industrial/Fine Chemicals;API intermediates;buffer
• Mol File: 115-69-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 100-110 °C(lit.)
• Boiling Point: 151 °C10 mm Hg(lit.)
• Flash Point: 109.7 °C
• Appearance: White/Crystalline Powder
• Density: 1.0509 (estimate)
• Vapor Density: 3.63 (vs air)
• Vapor Pressure: ~10 mm Hg ( 152 °C)
• Refractive Index: 1.4754 (estimate)
• Storage Temp.: Store at RT.
• Solubility: H2O: 1 M at 20 °C, clear, colorless
• PKA: 8.8(at 25℃)
• Water Solubility: 2500 g/L (20 ºC)
• Stability: Stable. Combustible. May be moisture-sensitive. Incompatible with strong oxidizing agents, copper, aluminium, brass, strong acid
• Merck: 13,447
• BRN: 635708
• CAS DataBase Reference: 2-Amino-2-methyl-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-2-methyl-1,3-propanediol(115-69-5)
• EPA Substance Registry System: 2-Amino-2-methyl-1,3-propanediol(115-69-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-37/39
• RIDADR: UN 3259 8/PG 2
• WGK Germany: 1
• RTECS: TY2975000
• F: 3-23
• TSCA: Yes
• PackingGroup: III
• Hazardous Substances Data: 115-69-5(Hazardous Substances Data)

Usage

Chemical Properties

white powder

Uses

Different sources of media describe the Uses of 115-69-5 differently. You can refer to the following data:
1. Emulsifying agent (in soap form) for oils, fats, and waxes; absorbent for acidic gases; organic synthesis; cosmetics.
2. A useful biological buffer2-Amino-2-methyl-1,3-propanediol is used to make surfactants, vulcanization accelerators and as a biological buffer. It acts as an absorbent for acidic gases and emulsifying agent for cosmetics, mineral oil, leather dressings, textile specialties and cleaning compounds. It is also used in hair sprays. It acts as a buffer for the determination of alkaline phosphatase activity and spacer in isotachophoresis of proteins. It serves as a reaction buffer for enzymes with an activity in the basic pH range such as alkaline phosphatase. Further, it is used in the preparation of 4-hydroxymethyl-4-methyl-oxazolidin-2-one.

Definition

ChEBI: An aminodiol that is propane-1,3-diol substituted ny an amino and a methyl group at position 2.

Purification Methods

Crystallise the diol three times from MeOH, dry in a stream of dry N2 at room temperature, then in a vacuum oven at 55o. Store it over CaCl2 [Hetzer & Bates J Phys Chem 66 308 1962]. [Beilstein 4 IV 1881.]

InChI:InChI=1/C4H11NO2/c1-4(5,2-6)3-7/h6-7H,2-3,5H2,1H3/p+1

Upstream product

• 84820-63-3 2-amino-2-methylpropan-1,3-diol acetate 
• 126-11-4 2-hydroxymethyl-2-nitro-propane-1,3-diol 
• 77-49-6 2-Methyl-2-nitro-1,3-propanediol 
• 22451-35-0 2-Amino-2-methyl-1,3-propandiol 
• 114444-46-1 C₁₄H₁₃NO 

Downstream Products

• 69184-33-4 4-Aza-3-hydroxymethyl-3-methyl-1-oxaspiro[4.5]decane 
• 39986-37-3 2,4-dimethyl-2-oxazoline-4-methanol 
• 14466-51-4 4-hydroxymethyl-4-methyl-2-heptadecyl-1,3-oxazoline 
• 120097-91-8 2-methyl-2-<<(7-methyl-7H-benzocarbazol-10-yl)methyl>amino>1,3-propanediol 
• 3129-78-0 1-(2-hydroxy-1-hydroxymethyl-1-methyl-ethyl)-3-phenyl-thiourea 
• 18278-95-0 2-((2-hydroxybenzylidene)amino)-2-methylpropane-1,3-diol 
• 50-00-0 formaldehyd 
• 7664-41-7 ammonia 
• 64-19-7 acetic acid 
• 96389-68-3 Crisnatol 
• 280753-14-2 2-amino-3-[tert-butyl(diphenyl)silyl]oxy-2-methylpropan-1-ol 
• 443308-46-1 (E,E)-1,4-bis-N-(1,3-dihydroxy-2-methylpropane-2-yl)-phenylene diimine 
• 391200-37-6 t-butyl (2-hydroxy-1-hydroxymethyl-1-methyl)ethylcarbamate 
• 2581-46-6 2-undecyl-4-hydroxymethyl-4-methyl-1,3-oxazoline 

Related news

Heat capacity and phase transition of 2-Amino-2-methyl-1,3-propanediol (cas 115-69-5) from 280 K to the melting point08/30/2019

The heat capacity of 2-amino-2-methyl-1,3-propanediol was measured from 280 K to the melting point by means of an automated adiabatic calorimeter. A bifurcated solid-solid transition for the compound was found with the maxima occurring at 352.89 and 353.72 K. The enthalpy of the bifurcated trans...detailed

Measurement of the thermal conductivities of 2-Amino-2-methyl-1,3-propanediol (cas 115-69-5) (AMP), 2-amino-2-hydroxymethyl-1,3-propanediol (TRIS) and the mixture (AMP+TRIS, mole ratio 50:50) in the temperature range from 20°C to their supermelting temperatures08/28/2019

2-Amino-2-methyl-1,3-propanediol (AMP), 2-amino-2-hydroxymethyl-1,3-propanediol (TRIS) and the mixture (AMP+TRIS, mole ratio 50:50) are being considered as potential candidates for the thermal storage of energy. The thermal conductivities have been measured with an uncertainty of ±3% from 20°C...detailed

2-Amino-2-methyl-1,3-propanediol (cas 115-69-5) (ampdH2) as ligand backbone for the synthesis of cobalt complexes: Mononuclear Co(II), binuclear Co(II,III) and hexanuclear Co(II,III)08/26/2019

Three cobalt complexes have been synthesized using 2-amino-2-methyl-1,3-propanediol (ampdH2) and its Schiff base derivative ligands and structurally characterized. The three complexes 1, 2 and 3 are very different and consist of mononuclear Co(II), mixed-valence binuclear Co(II,III) and mixed-va...detailed

Thermodynamic investigation of a solid–solid phase change material: 2-Amino-2-methyl-1,3-propanediol (cas 115-69-5) by calorimetric methods08/24/2019

An important solid–solid phase change heat storage material (PCM) 2-amino-2-methyl-1,3-propanediol was investigated by calorimetric methods. The molar heat capacities of the compound were measured in the temperature range from 78 to 405 K by means of a small sample automated adiabatic calorimet...detailed

Relevant articles and documents

PROCESS FOR THE PREPARATION OF NITROALCOHOLS

A process of preparing a nitroalcohol, e.g., 2-nitro-2-methyl-1-propane, from a nitropolyol, e.g., 2-nitro-2 -methyl-1,3-propanediol, the process comprising the step of contacting under hydrogenation conditions the nitropolyol with hydrogen, a hydrogenation catalyst and, optionally, a chelating agent.

A systematic entropy relationship for the general-base catalysis of the deprotonation of a carbon acid. A quantitative probe of transition-state solvation

The general-base-catalyzed deprotonation of a carbon acid, the l-methyl-4-(phenylacetyl)pyridinium cation (pKa = 9.02 at 25 °C), has been investigated for 32 general-base catalysts (25 amines and seven phenoxide ions) in aqueous solution. Amines give a generally scattered Bronsted plot; ring-substituted benzylamines have ?= 0.52, and ring-substituted phenoxides have ?= 0.60, with the phenoxides being more reactive than amines of similar basicity. The temperature dependences of the general-base-catalyzed deprotonation of this carbon acid have been measured over the range 15-45 °C for 12 base catalysts (eight primary, secondary, and tertiary amines; 4-(dimethylamino)pyridine; two phenoxide ions; hydroxide ion). The entropies of activation for these deprotonations show a clean curvilinear dependence upon the entropies of protonation of these base species, with the hydroxide ion being the only significant deviant from this relationship. This observation quantitatively establishes the importance of solvation effects as the major source of deviations that are commonly observed in Bronsted relationships for general-base-catalyzed processes.

Substituted pyridines

This invention relates to substituted pyridines prepared by reacting aldehydes, amines, lower carboxylic acids such as acetic acid in the presence of oxygen. The N-substituted pyridinium salts formed can be converted to pyridines by thermal dealkylation. The reactions can be summarized by the following equations: STR1