6631-69-2

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 501123-58-6 di[2-(4-hydroxyphenyl)]ethyl ether 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 

Downstream Products

• 501-94-0 p-hydroxyphenethyl alcohol 
• 6632-04-8 4-nitro-benzoic acid-[4-(2-iodo-ethyl)-phenyl ester] 
• 170962-05-7 4-(2-(diethylamino)ethyl)phenol 
• 100968-72-7 4-amino-2-hydroxy-benzoic acid-[4-(2-iodo-ethyl)-phenyl ester] 
• 74447-34-0 1-azido-2-(4-hydroxyphenyl)ethane 
• 539-15-1 N,N-dimethyltyramine 
• 6631-80-7 N-(4-hydroxyphenethyl)morpholine 
• 82966-19-6 1-<(4-Hydroxy-phenyl)-ethyl>-piperidin 

Relevant academic research and scientific papers

DNAzymes for amine and peptide lysine acylation

DNAzymes were previously identified by in vitro selection for a variety of chemical reactions, including several biologically relevant peptide modifications. However, finding DNAzymes for peptide lysine acylation is a substantial challenge. By using suita

Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation

An extensive range of functionalized aliphatic ketones with good functional-group tolerance has been prepared by a NiI-promoted coupling of either primary or secondary alkyl iodides with NN2 pincer NiII-acyl complexes. The latter were easily accessed from the corresponding NiII-alkyl complexes with stoichiometric CO. This Ni-mediated carbonylative coupling is adaptable to late-stage carbon isotope labeling, as illustrated by the preparation of isotopically labelled pharmaceuticals. Preliminary investigations suggest the intermediacy of carbon-centered radicals.

Transition-Metal-Free Borylation of Alkyl Iodides via a Radical Mechanism

We describe an operationally simple transition-metal-free borylation of alkyl iodides. This method uses commercially available diboron reagents as the boron source and exhibits excellent functional group compatibility. Furthermore, a diverse range of prim

Interaction of polycationic Ni(II)-salophen complexes with G-quadruplex DNA

A series of nine Ni(II) salophen complexes involving one, two, or three alkyl-imidazolium side-chains was prepared. The lengths of the side-chains were varied from one to three carbons. The crystal structure of one complex revealed a square planar geometr

Indium(III)-catalyzed reductive bromination and iodination of carboxylic acids to alkyl bromides and iodides: Scope, mechanism, and one-pot transformation to alkyl halides and amine derivatives

Highly effective indium(III)-catalyzed reductive bromination or iodination of a variety of carboxylic acids with 1,1,3,3-tetramethyldisiloxane (TMDS) and a source of bromine or iodine is described. This functional group interconversion has high tolerance for several functional groups, such as halogens, a hydroxy group, a nitro group, an olefin part, and a sulfide moiety. This indium catalytic system is also applicable to the reductive iodination of aldehyded, acyl chlorides, and esters. Furthermore, this reducing system can be applied to the one-pot synthesis of alkyl halides and amine derivatives via the addition of nucleophiles. Insight into the reaction mechanism was gained via the time course of 1H and 13C NMR monitoring experiments and the corresponding stepwise reactions.

Indium(III)-catalyzed one-pot synthesis of alkyl cyanides from carboxylic Acids

The one-pot preparation of alkyl cyanides from carboxylic acids via alkyl iodides or alkyl bromides, which were in situ generated either by indium(III)-catalyzed reductive iodination or bromination of carboxylic acids, is described. Georg Thieme Verlag Stuttgart New York.

Metallodendritic grafted core-shell γ-Fe2O3 nanoparticles used as recoverable catalysts in Suzuki C-C coupling reactions

The use of dendritic structures for the grafting of core-shell γ-Fe2O3/polymer 300 nm superparamagnetic nanoparticles (MNPs) has been performed with four metallodendrons that were functionalized with diphosphinopalladium complexes. The catalytic performance of these nanocatalysts was optimized for the Suzuki C-C cross-coupling reaction. These results demonstrated the importance of optimizing the catalytic efficiency of grafted MNPs by optimizing the dendritic structures and the nature of the peripheral phosphine ligands. All of these nanocatalysts showed remarkable reactivity towards bromoarenes and they were recovered and efficiently reused by magnetic separation with almost no loss of reactivity, even after 25 cycles. Copyright

Thermolysis of 4-(ω-hydroxyalkyl)-2,6-di-tert-butylphenols

The process of thermolysis of tert-butylated hydroxyalkyl phenols includes de-tert-butylation, etherification, and fragmentation of the hydroxyalkyl group. On the basis of the proposed schemes of the mechanism of thermal de-tert-butylation the path of the search for catalysts for the synthesis of 4-hydroxyalkylphenols is defined and transformations of the by-products into biologically active substances were considered.

PROPIONAMIDE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS

Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g. in the treatment or prevention of male hypogonadism and age-related conditions such as andropause.

Synthesis of 5-(ω-sulfhydrylalkyl)salicylaldehydes as precursors for the preparation of alkanethiol-modified metal salens

Using multistep syntheses, we obtained two alkanethiol-modified salicylaldehydes, namely 5-(2-sulfhydrylethyl)salicylaldehyde and 5-(6-sulfhydrylhexyl)salicylaldehyde. These compounds are precursors for the preparation of alkanethiol-substituted metal sal