66313-48-2

Basic information

• Product Name: 3-Oxazolidinecarbonyl chloride, 2-oxo- (9CI)
• Synonyms: 3-Oxazolidinecarbonyl chloride, 2-oxo- (9CI)
• CAS NO: 66313-48-2
• Molecular Formula: C₄H₄ClNO₃
• Molecular Weight: 149.53246
• Product Categories: ACIDHALIDE
• Mol File: 66313-48-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Oxazolidinecarbonyl chloride, 2-oxo- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxazolidinecarbonyl chloride, 2-oxo- (9CI)(66313-48-2)
• EPA Substance Registry System: 3-Oxazolidinecarbonyl chloride, 2-oxo- (9CI)(66313-48-2)

Safety Data

• Hazardous Substances Data: 66313-48-2(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 43112-38-5 3-(trimethylsilyl)-2-oxazolidinone 
• 497-25-6 dimethylenecyclourethane 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 10416-58-7 N,N-bis(trimethylsilyl)acetamide 

Relevant articles and documents

Design, synthesis, and biological evaluation of oxazolidone derivatives as highly potent N-acylethanolamine acid amidase (NAAA) inhibitors

N-Acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme that catalyzes the hydrolysis of endogenous fatty acid ethanolamides (FAEs), such as N-palmitoylethanolamide (PEA). PEA exhibits anti-inflammatory and analgesic activities by engaging peroxisome proliferator-activated receptor α (PPAR-α). Preventing PEA degradation by inhibition of NAAA has been proposed as a novel strategy for the treatment of inflammation and pain. In the present study, we reported the discovery of the oxazolidone derivative as a novel scaffold for NAAA inhibitors, and studied the structure-activity relationship (SAR) by modification of the side chain and terminal lipophilic substituents. The results showed that the link chain length of C5, straight and saturated linkages were the preferred shape patterns for NAAA inhibition. Several nanomolar NAAA inhibitors were described, including 2f, 3h, 3i and 3j with IC50 values of 270 nM, 150 nM, 100 nM and 190 nM, respectively. Enzymatic degradation studies suggested that 2f inhibited NAAA in a selective, noncompetitive and reversible pattern. Moreover, 2f showed high anti-inflammatory and analgesic activities after systemic and oral administration.

7-(N-substituted-2-phenylglycinamido)-3-substituted-3-cephem-4-carboxylic acid compounds and preparation thereof

New cephalosporin compounds of the formula: STR1 wherein R1 is hydrogen or hydroxy, R2 is a substituted alkanoyl group, R3 is hydrogen, carbamoyloxy, alkanoyloxy or a heterocyclic-thio group which may have suitable substituents, and R4 is carboxy or protected carboxy.