663177-71-7Relevant academic research and scientific papers
Synthesis of 4- and 6-substituted nitroindoles
Moskalev, Nikolai,Barbasiewicz, Micha?,Ma?kosza, Mieczys?aw
, p. 347 - 358 (2004)
Enolizable ketones react with m-nitroaniline in the presence of strong base such as t-BuOK to give 4- and 6-substituted nitroindoles. The reaction proceeds via oxidative nucleophilic substitution of hydrogen in m-nitroaniline with enolate anions in positions ortho to the amino group giving anionic σH adducts that are additionally stabilized by intramolecular interaction between the amino and the carbonyl group. Spontaneous oxidation of the σH adducts followed by the Bayer type condensation of the produced ortho-aminonitrobenzyl ketones gives 4- and 6-substituted nitroindoles. The scope of this reaction and its basic mechanistic features are discussed.
Asymmetric reduction of aryl imines using Candida parapsilosis ATCC 7330
Vaijayanthi,Chadha, Anju
, p. 93 - 96 (2008/09/17)
A highly enantioselective one pot, novel biocatalytic method for the asymmetric reduction of aryl imines is reported. Treatment of aryl imines with Candida parapsilosis ATCC 7330 in aqueous medium produces the enantiomerically pure (R)-secondary amines in
