6633-40-5

Basic information

• Product Name: 2-HYDROXY-7-NITROFLUORENE
• Synonyms: 7-Nitro-9H-fluoren-2-ol;7-Nitrofluoren-2-ol;NSC 56690;2-Hydroxy-7-nitro-9H-fluorene;7-Nitro
• CAS NO: 6633-40-5
• Molecular Formula: C13H9NO3
• Molecular Weight: 227.22
• Product Categories: Various Metabolites and Impurities;Metabolites & Impurities
• Mol File: 6633-40-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 452.4°C at 760 mmHg
• Flash Point: 198°C
• Appearance: /
• Density: 1.432g/cm³
• Vapor Pressure: 8.42E-09mmHg at 25°C
• Refractive Index: 1.713
• Storage Temp.: Refrigerator
• Solubility: DMSO, Ethyl Acetate
• CAS DataBase Reference: 2-HYDROXY-7-NITROFLUORENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-7-NITROFLUORENE(6633-40-5)
• EPA Substance Registry System: 2-HYDROXY-7-NITROFLUORENE(6633-40-5)

Safety Data

• Hazardous Substances Data: 6633-40-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 6633-40-5 differently. You can refer to the following data:
1. A major metabolite of 2-nitrofluorene (NF). It exhibits a significant estrogenic activity
2. A major metabolite of 2-nitrofluorene (NF). It exhibits a significant estrogenic activity.

General Description

Solid.

Fire Hazard

Flash point data for 2-HYDROXY-7-NITROFLUORENE are not available. 2-HYDROXY-7-NITROFLUORENE is probably combustible.

InChI:InChI=1/C13H9NO3/c15-11-2-4-13-9(7-11)5-8-6-10(14(16)17)1-3-12(8)13/h1-4,6-7,15H,5H2

Upstream product

• 86-73-7 9H-fluorene 
• 19383-83-6 7-Nitro-2-acetoxy-fluoren 
• 781-73-7 1-(9H-fluoren-2-yl)ethanone 
• 5405-53-8 2,7-dinitro-9H-fluorene 
• 34172-49-1 1-(7-nitro-9H-fluorene-2-yl)ethanone 
• 1214-32-0 2-amino-7-nitrofluorene 

Downstream Products

• 54961-21-6 2-methoxy-7-nitrofluorene 
• 363-49-5 7-hydroxy-2-acetylaminofluorene 
• 52057-78-0 2-Methoxy-7-aminofluoren 
• 92901-08-1 7-methoxy-N-hydroxy-2-acetamidofluorene 
• 1953-38-4 7-hydroxy-2-aminofluorene 

Relevant articles and documents

Cross-conjugation vs. linear conjugation in donor-bridge-acceptor nitrophenol chromophores

The influence of cross-conjugation vs. linear conjugation on the electronic communication between donor and acceptor groups in phenol(ate)-bridge- nitrobenzene chromophores was investigated by solution and gas-phase absorption spectroscopy, fluorescence s

Preneoplastic lesions, DNA adduct formation and mutagenicity of 5-, 7- and 9 -hydroxy-2-nitrofluorene, metabolites of the air pollutant 2-nitrofluorene

The metabolites of 2-nitrofluorene (NF), 5-, 7- and 9-OH-2-nitrofluorene (OH-NF) were compared for their genotoxicity. Seventy-two hours after intraperitoneal administration of these substances individually to rats (100 mg/kg body wt.), DNA adducts in liver tissue were analyzed with 32P-TLC and 32P-HPLC. An in vivo liver model was used to test the initiating capacity of the said substances for the formation of preneoplastic lesions. 5-OH-NF showed low capacity to induce DNA adduct formation and low potential as initiator to induce preneoplastic lesions-foci/nodules in the liver of rats. Both 7- and 9-OH-NF induced DNA adducts and preneoplastic liver lesions but with smaller quantities compared to NF. It seems that 7- and 9-OH-NF can not be considered as detoxification products of NF. In general, the initiating capacity of these substances for the formation of preneoplastic lesions has a good correlation with their potency to form DNA adducts.