6633-40-5

Usage

Uses

Used in Pharmaceutical Industry:
2-HYDROXY-7-NITROFLUORENE is used as a pharmaceutical compound for its significant estrogenic activity. This characteristic makes it a potential candidate for the development of drugs targeting estrogen-related conditions and therapies.
Used in Research and Development:
In the field of research and development, 2-HYDROXY-7-NITROFLUORENE serves as an important chemical intermediate for the synthesis of various compounds with potential applications in medicine and other industries. Its unique chemical properties allow scientists to explore its potential in creating new drugs and materials.
Used in Environmental Monitoring:
As a metabolite of 2-nitrofluorene, 2-HYDROXY-7-NITROFLUORENE can be used in environmental monitoring to detect the presence of pollutants and assess the impact of industrial activities on the environment. This application helps in understanding the extent of pollution and taking necessary measures to mitigate its effects.
Used in Analytical Chemistry:
The chemical properties of 2-HYDROXY-7-NITROFLUORENE make it a useful compound in analytical chemistry for various purposes, such as the development of new analytical methods, the detection of specific substances, and the study of chemical reactions and interactions.

Fire Hazard

Flash point data for 2-HYDROXY-7-NITROFLUORENE are not available. 2-HYDROXY-7-NITROFLUORENE is probably combustible.

InChI:InChI=1/C13H9NO3/c15-11-2-4-13-9(7-11)5-8-6-10(14(16)17)1-3-12(8)13/h1-4,6-7,15H,5H2

Upstream product

• 1214-32-0 2-amino-7-nitrofluorene 
• 34172-49-1 1-(7-nitro-9H-fluorene-2-yl)ethanone 
• 5405-53-8 2,7-dinitro-9H-fluorene 
• 781-73-7 1-(9H-fluoren-2-yl)ethanone 
• 19383-83-6 7-Nitro-2-acetoxy-fluoren 
• 86-73-7 9H-fluorene 

Downstream Products

• 1953-38-4 7-hydroxy-2-aminofluorene 
• 54961-21-6 2-methoxy-7-nitrofluorene 
• 363-49-5 7-hydroxy-2-acetylaminofluorene 
• 52057-78-0 2-Methoxy-7-aminofluoren 
• 92901-08-1 7-methoxy-N-hydroxy-2-acetamidofluorene 

Relevant academic research and scientific papers

Cross-conjugation vs. linear conjugation in donor-bridge-acceptor nitrophenol chromophores

The influence of cross-conjugation vs. linear conjugation on the electronic communication between donor and acceptor groups in phenol(ate)-bridge- nitrobenzene chromophores was investigated by solution and gas-phase absorption spectroscopy, fluorescence s

Molecular engineering of organic sensitizers with planar bridging units for efficient dye-sensitized solar cells

Here comes the sun: Three highly efficient organic sensitizers with sterically hindered fluorenyl units and planar indenothiophene derivatives were designed and synthesized (see figure). Devices based on one of these compounds, JK-303, gave overall conversion efficiencies of 8.69, 9.04, 7.27, and 5.82 % using I-/I3-, CoII/CoIII, polymer gel, and solid-state electrolytes, respectively. These efficiencies are some of the highest reported for DSSCs based on organic sensitizers. Copyright

Preneoplastic lesions, DNA adduct formation and mutagenicity of 5-, 7- and 9 -hydroxy-2-nitrofluorene, metabolites of the air pollutant 2-nitrofluorene

The metabolites of 2-nitrofluorene (NF), 5-, 7- and 9-OH-2-nitrofluorene (OH-NF) were compared for their genotoxicity. Seventy-two hours after intraperitoneal administration of these substances individually to rats (100 mg/kg body wt.), DNA adducts in liver tissue were analyzed with 32P-TLC and 32P-HPLC. An in vivo liver model was used to test the initiating capacity of the said substances for the formation of preneoplastic lesions. 5-OH-NF showed low capacity to induce DNA adduct formation and low potential as initiator to induce preneoplastic lesions-foci/nodules in the liver of rats. Both 7- and 9-OH-NF induced DNA adducts and preneoplastic liver lesions but with smaller quantities compared to NF. It seems that 7- and 9-OH-NF can not be considered as detoxification products of NF. In general, the initiating capacity of these substances for the formation of preneoplastic lesions has a good correlation with their potency to form DNA adducts.

Mechanism-Based Inactivation of N-Arylhydroxamic Acid N,O-Acyltransferase by 7-Substituted-N-hydroxy-2-acetamidofluorenes

N-Arylhydroxamic acid N,O-acyltransferase (AHAT) catalyzes the transfer of the N-acetyl group from N-arylhydroxamic acids to arylamines.In the absence of an arylamine acceptor, AHAT catalyzes the conversion of N-arylhydroxamic acids to reactive electrophilic intermediates that become irreversibly bound to cellular nucleophiles, including those present on AHAT itself.As a part of an investigation of the AHAT-catalyzed bioactivation process, a series of 7-substituted analogues of N-hydroxy-2-acetamidofluorene (1) was synthesized and evaluated in vitro as substrates andinactivators of a partially purified hamster hepatic AHAT preparation.All of the compounds functioned as acetyl donors in the AHAT-catalyzed transacetylation of 4-aminoazobenzene (AAB) and all of them were inactivators of AHAT.The inactivation process exhibited apparent first-order kinetics, and the 7-methoxy compound exhibited the largest inactivation rate constant.Quantitative structure-activity analysis provided support for the concept that positively charged species are involved in the inactivation of AHAT by this series of compounds.Results of experiments in which nucleophilic trapping agents such as glutathione, cysteine, methionine, guanosine phosphate, and tRNA were included in incubation mixtures with AHAT and the N-arylhydroxamic acids indicated that electrophiles which diffuse away from the enzyme active site participate in the inactivation process.