2-Hydroxy-7-nitrofluorene

Base Information

• Chemical Name: 2-Hydroxy-7-nitrofluorene
• CAS No.: 6633-40-5
• Molecular Formula: C₁₃H₉NO₃
• Molecular Weight: 227.219
• Hs Code.: 2906299090
• NSC Number: 56690
• DSSTox Substance ID: DTXSID2074871
• Wikidata: Q27461148
• ChEMBL ID: CHEMBL165314
• Mol file: 6633-40-5.mol

Synonyms:2-hydroxy-7-nitrofluorene

Chemical Property of 2-Hydroxy-7-nitrofluorene

Chemical Property:

• Vapor Pressure: 8.42E-09mmHg at 25°C
• Boiling Point: 452.4°C at 760 mmHg
• Flash Point: 198°C
• PSA: 66.05000
• Density: 1.432g/cm³
• LogP: 3.39480
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Ethyl Acetate
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 227.058243149
• Heavy Atom Count: 17
• Complexity: 314

Purity/Quality:

99% ^*data from raw suppliers

7-Nitrofluoren-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C=CC(=C2)[N+](=O)[O-])C3=C1C=C(C=C3)O
• Uses: A major metabolite of 2-nitrofluorene (NF). It exhibits a significant estrogenic activity A major metabolite of 2-nitrofluorene (NF). It exhibits a significant estrogenic activity.

Technology Process of 2-Hydroxy-7-nitrofluorene

There total 8 articles about 2-Hydroxy-7-nitrofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-amino-7-nitrofluorene (1214-32-0) → 7-hydroxy-2-nitrofluorene (6633-40-5)

Guidance literature:

DOI:10.1016/S0165-1218(96)90022-1

Reference yield:

1-(7-nitro-9H-fluorene-2-yl)ethanone (34172-49-1) → 7-hydroxy-2-nitrofluorene (6633-40-5)

Guidance literature:

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; Yield given. Multistep reaction; 1.) CHCl₃, 10 d, 2.) aq. EtOH, reflux, 3.5 h;

DOI:10.1021/jm00379a005

Reference yield:

→ 7-hydroxy-2-nitrofluorene (6633-40-5)

Guidance literature:

With nitric acid; acetic acid; at 80 ℃;

upstream raw materials:

2-amino-7-nitrofluorene

1-(7-nitro-9H-fluorene-2-yl)ethanone

2,7-dinitro-9H-fluorene

1-(9H-fluoren-2-yl)ethanone

Downstream raw materials:

2-methoxy-7-nitrofluorene

7-hydroxy-2-acetylaminofluorene

2-Methoxy-7-aminofluoren

7-methoxy-N-hydroxy-2-acetamidofluorene

Refernces

• 1、 Lim, Kimin,Ju, Myung Jong,Na, Jongbeom,Choi, Hyeju,Song, Min Young,Kim, Byeonggwan,Song, Kihyung,Yu, Jong-Sung,Kim, Eunkyoung,Ko, Jaejung. "Molecular engineering of organic sensitizers with planar bridging units for efficient dye-sensitized solar cells". . p. 9442 - 9446. Retrieved 2013/07/26.
• 2、 Marhevka, Virginia C.,Ebner, Nancy A.,Sehon, Russell D.,Hanna, Patrick E.. "Mechanism-Based Inactivation of N-Arylhydroxamic Acid N,O-Acyltransferase by 7-Substituted-N-hydroxy-2-acetamidofluorenes". . p. 18 - 24. Retrieved 2007/10/02.