6633-69-8

Basic information

• Product Name: N4-(4-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine
• Synonyms: N4-(4-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine
• CAS NO: 6633-69-8
• Molecular Formula: C₁₁H₁₁BrN₄
• Molecular Weight: 279
• Mol File: 6633-69-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 476.2°C at 760 mmHg
• Flash Point: 241.8°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 3.12E-09mmHg at 25°C
• Refractive Index: 1.703
• CAS DataBase Reference: N4-(4-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N4-(4-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine(6633-69-8)
• EPA Substance Registry System: N4-(4-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine(6633-69-8)

Safety Data

• Hazardous Substances Data: 6633-69-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11BrN4/c1-7-6-10(16-11(13)14-7)15-9-4-2-8(12)3-5-9/h2-6H,1H3,(H3,13,14,15,16)

Upstream product

• 3977-29-5 2-amino-6-methylpyrimidin-4-ol 
• 5600-21-5 2-amino-6-methyl-4-chloropyrimidine 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 6633-70-1 5-bromo-N⁴-(4-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine 

Relevant articles and documents

Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors

Interleukin-1β converting enzyme contributes in various inflammatory and autoimmune diseases by maturing pro-inflammatory cytokines IL-1β, IL-18 and IL-33. Therefore, inhibition caspase-1 may provide a potential therapeutic strategy for the treatment of chronic inflammatory diseases. Here we have reported structure-based design, synthesis and biological evaluation of 2,4-diaminopyrimidine derivatives (6a-6w) as potential caspase-1 inhibitors. Six compounds 6m, 6n, 6o, 6p, 6q and 6r showed significant enzymatic inhibition with IC5 0 ranging from 0.022 to 0.078 μM. These compounds also displayed excellent cellular potency at sub-micromolar concentration. Moreover, molecular docking studies provided the useful binding insights specific for caspase-1 inhibition. All these results indicated that compounds 6m, 6n and 6o could be potential leads for the development of newer caspase-1 inhibitors as anti-inflammatory agents.