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N4-(4-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine is a chemical compound with the molecular formula C11H10BrN5. It is a derivative of pyrimidine, a heterocyclic aromatic organic compound consisting of a six-membered ring with four carbon atoms and two nitrogen atoms. This specific compound features a 4-bromo-phenyl group attached to the N4 position and a methyl group at the 6 position of the pyrimidine ring. The 2,4-diamine part of the name indicates the presence of two amino groups (-NH2) at the 2 and 4 positions of the pyrimidine ring. N4-(4-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine is of interest in the field of organic chemistry and may have potential applications in the synthesis of pharmaceuticals or other chemical products due to its unique structure and functional groups.

6633-69-8

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6633-69-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6633-69-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,3 and 3 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6633-69:
(6*6)+(5*6)+(4*3)+(3*3)+(2*6)+(1*9)=108
108 % 10 = 8
So 6633-69-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H11BrN4/c1-7-6-10(16-11(13)14-7)15-9-4-2-8(12)3-5-9/h2-6H,1H3,(H3,13,14,15,16)

6633-69-8Relevant academic research and scientific papers

Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors

Patel, Shivani,Modi, Palmi,Ranjan, Vishal,Chhabria, Mahesh

, p. 258 - 268 (2018/04/05)

Interleukin-1β converting enzyme contributes in various inflammatory and autoimmune diseases by maturing pro-inflammatory cytokines IL-1β, IL-18 and IL-33. Therefore, inhibition caspase-1 may provide a potential therapeutic strategy for the treatment of chronic inflammatory diseases. Here we have reported structure-based design, synthesis and biological evaluation of 2,4-diaminopyrimidine derivatives (6a-6w) as potential caspase-1 inhibitors. Six compounds 6m, 6n, 6o, 6p, 6q and 6r showed significant enzymatic inhibition with IC5 0 ranging from 0.022 to 0.078 μM. These compounds also displayed excellent cellular potency at sub-micromolar concentration. Moreover, molecular docking studies provided the useful binding insights specific for caspase-1 inhibition. All these results indicated that compounds 6m, 6n and 6o could be potential leads for the development of newer caspase-1 inhibitors as anti-inflammatory agents.

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