66343-79-1Relevant academic research and scientific papers
Selective oxidation of alcohol-d1to aldehyde-d1using MnO2
Kitsuwa, Kohei,Kumadaki, Katsushi,Nakayama, Atsushi,Okamura, Hironori,Ozawa, Keita,Shinada, Tetsuro,Tamura, Yusaku,Yamamoto, Yuki,Yasuno, Yoko
, p. 28530 - 28534 (2021/09/22)
The selective oxidation of alcohol-d1to prepare aldehyde-d1was newly developed by means of NaBD4reduction/activated MnO2oxidation. Various aldehyde-d1derivatives including aromatic and unsaturated ald
Phthalazinone compound and preparation method, pharmaceutical composition and use thereof
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Paragraph 0134-0138, (2019/01/23)
The invention relates to a phthalazinone compound and a preparation, pharmaceutical composition and use thereof, wherein the structure of the phthalazinone compound is shown as formula one, and the compound of the formula one is targeted to a virus nuclea
Frustrated Lewis pairs: A real alternative to deuteride/tritide reductions
Doubková, Sabina,Marek, Ale?
, p. 729 - 742 (2019/07/10)
Deuterium- and tritium-labeled compounds play a principal role in tracing of biologically active molecules in complicated biochemical systems. The state-of-the-art techniques using noble metal catalysts or strong reducing agents often suffers from low fun
One-Pot Synthesis of Quinazolin-4(3H)-ones through Anodic Oxidation and the Related Mechanistic Studies
Cao, Liu,Huo, Hengrui,Zeng, Haipeng,Yu, Yu,Lu, Dengfu,Gong, Yuefa
supporting information, p. 4764 - 4773 (2018/11/10)
A metal-free and oxidant-free method for the one-pot preparation of quinazolin-4(3H)-ones enabled by electrochemical oxidation is described. Together with 2-aminobenzamides, a variety of aldehydes were successfully applied to an acid-catalyzed annulation and direct anodic oxidation cascade, affording structurally diverse quinazoline-4(3H)-ones in good to excellent yields. Additionally, certain alcohols can be directly applied instead of the corresponding aldehydes to achieve the same final products with the assistance of an electrolysis mediator (TEMPO). The reaction mechanism was carefully examined and the results strongly suggest that the direct and indirect oxidation go through different pathways. As an efficient and environmentally friendly access to a broad range of quinazolin-4(3H)-ones, the synthetic utility of this method was demonstrated by gram-scale operation, as well as the preparation of bioactive mackinazolinone and truncated erlotinib. (Figure presented.).
Synthesis of optically active benzyl-α-d alcohols by asymmetric hydrogenation of benzaldehyde-α-d and its derivatives catalyzed by BINAP-Ru(II) complexes
Ohta, Tetsuo,Tsutsumi, Takaharu,Takaya, Hidemasa
, p. 191 - 194 (2007/10/02)
Optically active benzyl-α-d alcohols have been synthesized in up to 89percent ee by asymmetric hydrogenation of benzaldehyde-α-d and its derivatives catalyzed by BINAP-Ru(II) complexes.A remarkable enhancement in enantioselectivities has been observed for
