7455-77-8

Basic information

• Product Name: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-
• Synonyms: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-;2-(4-chlorophenyl)quinazolin-4-ol;2-(4-chlorophenyl)-4(1H)-quinazolinone;2-(4-CHLOROPHENYL)QUINAZOLIN-4(3H)-ONE
• CAS NO: 7455-77-8
• Molecular Formula: C₁₄H₉ClN₂O
• Molecular Weight: 256.68706
• Mol File: 7455-77-8.mol
• Article Data: 181

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-(7455-77-8)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 2-(4-chlorophenyl)-(7455-77-8)

Safety Data

• Hazardous Substances Data: 7455-77-8(Hazardous Substances Data)

Upstream product

• 52962-92-2 2-(4-Chlorobenzamido)benzamide 
• 104-88-1 4-chlorobenzaldehyde 
• 28144-70-9 anthranilic acid amide 
• 74-11-3 para-chlorobenzoic acid 
• 623-03-0 4-Cyanochlorobenzene 
• 134-20-3 2-carbomethoxyaniline 
• 118-48-9 isatoic anhydride 
• 10345-77-4 2-nitro-N,N-diethylbenzamide 
• 122-01-0 4-chloro-benzoyl chloride 
• 118-92-3 anthranilic acid 
• 62102-59-4 2-(4-chlorophenyl)-1,3-benzodithiole 
• 619-56-7 4-chlorobenzamide 
• 88-67-5 2-Iodobenzoic acid 
• 14401-51-5 4-chlorobenzamidine hydrochloride 

Downstream Products

• 1382529-56-7 2-(4-chlorophenyl)-4-p-tolylsulfanylquinazoline 
• 1382529-57-8 2-(4-chlorophenyl)-4-phenylsulfanylquinazoline 
• 1382529-58-9 2-(4-chlorophenyl)-4-(4-fluorophenylsulfanyl)quinazoline 
• 1382529-59-0 2-(4-chlorophenyl)-4-(4-chlorophenylsulfanyl)quinazoline 
• 900613-41-4 C₁₅H₁₀ClN₅ 
• 105250-97-3 2-(4-chloro-phenyl)-3H-quinazolin-4-thione 
• 315715-71-0 C₁₄H₁₁ClN₄ 
• 1429045-91-9 C₂₈H₁₉ClN₆S 
• 1229610-04-1 2-(4-chloro-phenyl)-4-phenyl-quinazoline 
• 1520087-46-0 2-(4-chlorophenyl)-4-(p-tolyl)quinazoline 
• 1520087-48-2 2-(4-chlorophenyl)-4-(chlorophenyl)quinazoline 

Relevant articles and documents

A bagasse-supported magnetic manganese dioxide nanoparticle: applications in the selective aerobic oxidation of alcohols and one-pot tandem oxidative synthesis of quinazolinones

Magnetic manganese dioxide nanoparticles (MnO2-Fe3O4) were coated on sugarcane bagasse as a sugar industrial waste and bio-support (MnO2-Fe3O4@bagasse) via an in situ reduction strategy, in which potassium permanganate was used as the precursor of MnO2 and sugarcane bagasse as a bio-support and reducing agent of KMnO4. The synthesized bio-based catalyst was characterized by X-ray diffraction, thermogravimetric analysis, inductively coupled plasma optical emission spectroscopy, scanning electron microscopy, energy dispersive spectroscopy, Brunauer–Emmett–Teller surface area analysis, and vibrating sample magnetometer analysis. The catalyst was successfully utilized in the selective aerobic oxidation of primary and secondary benzylic alcohols to their corresponding carbonyl compounds and one-pot tandem oxidative synthesis of 2-(substituted)quinazoline-4(3H)-ones from the o-aminobenzamide and aromatic alcohols in the absence of oxidizing reagent or initiator. Graphical abstract: [Figure not available: see fulltext.]

Access to 2-Arylquinazolin-4(3H)-ones through Intramolecular Oxidative C(sp3)?H/N?H Cross-Coupling Mediated by I2/DMSO

A novel approach for the synthesis of 2-arylquinazolin-4(3H)-ones was developed. A series of title compounds were obtained with good functional group tolerance and good yields by I2/DMSO-mediated intramolecular oxidative cross-coupling of 2-(benzylamino)benzamides to form C=N double bonds. This method was applicable for gram-scale synthesis. A proposed reaction pathway based on some control experiments was also provided.

Preparation method of quinazolinone derivative

The invention discloses a preparation method of a quinazolinone derivative, wherein the preparation method comprises the following steps: dissolving an anthranilonitrile compound represented by a formula I and an aldehyde represented by a formula II in a