66343-90-6

Basic information

• Product Name: 1-p-Chlorphenyl-aceton-tosylhydrazon
• Synonyms: 1-p-Chlorphenyl-aceton-tosylhydrazon
• CAS NO: 66343-90-6
• Molecular Weight: 336.842
• Mol File: 66343-90-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-p-Chlorphenyl-aceton-tosylhydrazon(CAS DataBase Reference)
• NIST Chemistry Reference: 1-p-Chlorphenyl-aceton-tosylhydrazon(66343-90-6)
• EPA Substance Registry System: 1-p-Chlorphenyl-aceton-tosylhydrazon(66343-90-6)

Safety Data

• Hazardous Substances Data: 66343-90-6(Hazardous Substances Data)

Upstream product

• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 5586-88-9 1-(4-chlorophenyl)propan-2-one 

Downstream Products

• 2809-65-6 4-chloro-1-propynylbenzene 

Relevant articles and documents

Copper-catalyzed aerobic oxidative transformation of ketone- Derived N-tosyl hydrazones: An entry to alkynes

A novel strategy involving Cu-catalyzed oxidative transformation of ketone-derived hydrazone moiety to various synthetic valuable internal alkynes and diynes has been developed. This method features inexpensive metal catalyst, green oxidant, good functional group tolerance, high regioselectivity and readily available starting materials. Oxidative deprotonation reactions were carried out to form internal alkynes and symmetrical diynes. Cross-coupling reactions of hydrazones with halides and terminal alkynes were performed to afford functionalized alkynes and unsymmetrical conjugated diynes. A mechanism proceeding through a Cu-carbene intermediate is proposed for the CC triple bond formation.