66346-02-9Relevant academic research and scientific papers
Design, synthesis and neuraminidase inhibitory activity of N-(5-benzyl-4-(tert-butyl)thiazol-2-yl)benzamides
Wu, Zhilin,Peng, Junmei,Hu, Aixi,Ye, Jiao,Li, Guoxi
, p. 356 - 368 (2016/01/25)
A series of N-(5-benzyl-4-(tert-butyl)thiazol-2-yl)benzamides were synthesized and the structures were characterized by 1H NMR, MS and elemental analyses. The crystal structures of compounds F5 and F16 were determined by single-crystal X-ray diffraction. The neuraminidase inhibitory activities of compounds F1-F32 were evaluated in vitro at the concentration of 40 μg/mL. The results indicated that compounds F8, F26 and F32 exhibited most potent inhibitory activity against NA. Molecular docking was performed by LeDock to further explain the structure-activity relationship of compound F26. The docking modeling showed that compound F26 was in good combination with oseltamivir binding sites of NA and could be a potential NA inhibitor agent.
Regioselective one-pot bromination of 4,4-dimethyl-1-aryl-3-pentanones with [Bmim]Br3 or [BMPy]Br3 under solvent-free conditions
Cao, Gao,Wang, Ying,Zhou, Zhen
experimental part, p. 479 - 484 (2012/07/27)
An efficient and environmentally benign bromination of 4,4-dimethyl-1-aryl- 3- pentanones with 1-butyl-3-methylimidazolium tribromide ([Bmim]Br3) or 1-butyl-3-methylpyridinium tribromide ([BMPy]Br3) as the bromine source is elaborated. Investigation of the protocol revealed that the method operates for the title carbonyl compounds producing the corresponding monobrominated products in good to excellent yields (90.2% ～ 95.1%). The ionic liquids [Bmim]Br and [BMPy]Br are recyclable and can be reused with minimal loss, which minimizes the use of organic solvents and enhances the chemical reactivity and selectivity.
Hydrogen-bonded helices in 2-aminothiazole derivatives: Generation of chiral crystals from small achiral molecules
Hu, Aixi,Cao, Gao
experimental part, p. 1332 - 1336 (2011/11/29)
The hydrobromide and nitrate of 4-(tert-butyl)-5-(4-chlorobenzyl)thiazol-2- amine have been synthesized, and their chiral symmetry breaking in the solid-state has been investigated. It is shown that each molecule is connected by continuous N-H...Br/N-H...
Fungicidal compounds
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, (2008/06/13)
Triazoles of formula: STR1 wherein R1 is alkenyl, alkynyl or optionally substituted aralkyl; Y is =N--, R2 is cycloalkyl, alkyl or haloalkyl, and R3 is H, methyl or alkenyl, or esters, ethers, salts and metal complexes thereof. The triazoles have fungicidal and plant growth regulating activity.
