6635-67-2

Basic information

• Product Name: 1-cyclopentylpropan-1-one
• Synonyms: 1-cyclopentylpropan-1-one;1-cyclopentylpropan-1-one(SALTDATA: FREE);1-Propanone, 1-cyclopentyl-
• CAS NO: 6635-67-2
• Molecular Formula: C₈H₁₄O
• Molecular Weight: 126.2
• Mol File: 6635-67-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 178.8°C at 760 mmHg
• Flash Point: 60.4°C
• Appearance: /
• Density: 0.924g/cm³
• Vapor Pressure: 0.971mmHg at 25°C
• Refractive Index: 1.453
• CAS DataBase Reference: 1-cyclopentylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopentylpropan-1-one(6635-67-2)
• EPA Substance Registry System: 1-cyclopentylpropan-1-one(6635-67-2)

Safety Data

• Hazardous Substances Data: 6635-67-2(Hazardous Substances Data)

Usage

General Description

1-cyclopentylpropan-1-one, also known as cyclopentylacetone, is a chemical compound with the molecular formula C8H14O. It is a cyclic ketone and a key intermediate in the synthesis of pharmaceuticals and organic compounds. This chemical has a characteristic fruity odor and is commonly used as a flavoring and fragrance agent in the food and cosmetic industries. It is also used in the production of fragrances, rubber chemicals, and other organic compounds. Additionally, 1-cyclopentylpropan-1-one is known for its potential use in the development of new drugs and pharmaceuticals due to its unique chemical properties.

InChI:InChI=1/C8H14O/c1-2-8(9)7-5-3-4-6-7/h7H,2-6H2,1H3

Upstream product

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• 925-90-6 ethylmagnesium bromide 
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• 822-87-7 2-Chlorocyclohexanone 
• 71911-62-1 6-<1,1-bis(ethoxycarbonyl)ethyl>bicyclo<3.1.0>hexan-6-ol 
• 7553-56-2 iodine 

Relevant articles and documents

Malonate Anion Induced Favorskii-Type Rearrangement. Reaction of Cyclic α-Halo Ketones with Sodiomalonates

The reaction of 2-chlorocyclohexanone (1b) with ethyl sodiomalonate in benzene at 0-25 deg C gave 6-bicyclohexan-6-ol (4c), the Favorskii-type intermediate, in 49percent yield, in place of the substitution product ethyl C-(2-oxocyclohexyl)malonate (3).Derivatives of bicycloheptan-7-ol (4a,b) and those of bicyclohexan-6-ol (4d,e) were also obtained in good yields by similar means.Compound 4c was transformed into 3 readily by heating with 0.05 equiv of NaH in benzene.The hydrolysis of 4a-d with 0.2 N NaOH followed by pyrolysis at 110-120 deg C gave the ring-contracted β-keto esters 9a-d.Pyrolysis after the hydrolysis with 2N NaOH gave the corresponding ketones 11a-d in good yields.Oxidation of 4c with CrO3 and HClO4 afforded ethyl C-(2-hydroxycyclopentanecarbonyl)malonate (14) in 45 percent yield.Treatment of 4c with Br2 gave ethyl C-(1-bromocyclopentanecarbonyl)malonate (18) in 64 percent yield.