6635-92-3

Basic information

• Product Name: N-(6-chloro-4-methyl-pyridin-3-yl)acetamide
• Synonyms: N-(6-chloro-4-methyl-pyridin-3-yl)acetamide;5-Acetamido-2-chloro-4-picoline
• CAS NO: 6635-92-3
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.63
• Product Categories: Heterocyclic Compounds
• Mol File: 6635-92-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 155-156 °C
• Boiling Point: 349.4 °C at 760 mmHg
• Flash Point: 165.1 °C
• Appearance: /
• Density: 1.282 g/cm³
• Vapor Pressure: 4.73E-05mmHg at 25°C
• Refractive Index: 1.586
• PKA: 13.32±0.70(Predicted)
• CAS DataBase Reference: N-(6-chloro-4-methyl-pyridin-3-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-chloro-4-methyl-pyridin-3-yl)acetamide(6635-92-3)
• EPA Substance Registry System: N-(6-chloro-4-methyl-pyridin-3-yl)acetamide(6635-92-3)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 6635-92-3(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C8H9ClN2O/c1-5-3-8(9)10-4-7(5)11-6(2)12/h3-4H,1-2H3,(H,11,12)

Upstream product

• 21901-40-6 2-amino-5-nitro-4-picoline 
• 21901-41-7 2-hydroxy-4-methyl-5-nitropyridine 
• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 108-24-7 acetic anhydride 
• 66909-38-4 5-amino-2-chloro-4-methylpyridine 

Downstream Products

• 76006-08-1 5-chloro-1H-pyrazolo<3,4-c>pyridine 
• 76006-04-7 1-acetyl-5-chloro-1H-pyrazolo<3,4-c>pyridine 
• 76006-08-1 5-chloropyrazolo[3,4-c]pyridine 
• 1951402-78-0 5,7-dichloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-c]pyridine 

Relevant articles and documents

Synthesis, docking study and kinase inhibitory activity of a number of new substituted pyrazolo[3,4-c]pyridines

A series of new pyrazolo[3,4-c]pyridines bearing various 1, 3, 5 or 1, 3, 7 pattern substitutions, were designed and synthesized. Some of them showed interesting inhibitory activity mainly against glycogen synthase kinase 3 (GSK3)α/β as well as against cdc2-like kinases 1 (CLK1) and dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), with good selectivity and remarkable structure-activity relationships (SARs), without being cytotoxic. Molecular simulations in correlation with biological data revealed the importance of the existence of N1-H as well as the absence of a bulky 7-substituent.

The discovery of new cytotoxic pyrazolopyridine derivatives

A number of new 3,7-disubstituted pyrazolo[3,4-c]pyridines have been designed and synthesized from suitable 2-aminopyridines. The antiproliferative activity of the derivatives was determined against the pancreatic MIA PaCa-2 and ovarian SCOV3 cancer cell-lines. IC50values of the most promising analogue 46 lie in the submicromolar or low micromolar range. Furthermore, compound 46 shows similar inhibitory activities against DU145, A2058 and PC-3 cancer cells, blocks the cell cycle at the G0/G1phase and induce apoptosis, as determined by the appearance of apoptotic nuclei.