66353-69-3 Usage
Uses
Used in Pharmaceutical Industry:
[3-amino-4-(methylamino)phenyl] phenyl ketone is used as an intermediate in the synthesis of 1-Methyl Mebendazole (M320150), a related compound with anthelmintic properties. It plays a crucial role in the development of new anthelmintic agents, which are essential for treating infections caused by parasitic worms.
Additionally, it is used in the synthesis of Mebendazole USP Related Compound D, which is another anthelmintic agent. [3-amino-4-(methylamino)phenyl] phenyl ketone is valuable in the pharmaceutical industry for its potential applications in treating various helminthic infections and improving the overall health of affected individuals.
Check Digit Verification of cas no
The CAS Registry Mumber 66353-69-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,3,5 and 3 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 66353-69:
(7*6)+(6*6)+(5*3)+(4*5)+(3*3)+(2*6)+(1*9)=143
143 % 10 = 3
So 66353-69-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H14N2O/c1-16-13-8-7-11(9-12(13)15)14(17)10-5-3-2-4-6-10/h2-9,16H,15H2,1H3
66353-69-3Relevant academic research and scientific papers
Synthesis and antiparasitic activity of Albendazole and Mebendazole analogues
Navarrete-Vazquez, Gabriel,Yepez, Lilian,Hernandez-Campos, Alicia,Tapia, Amparo,Hernandez-Luis, Francisco,Cedillo, Roberto,Gonzalez, Jose,Martinez-Fernandez, Antonio,Martinez-Grueiro, Mercedes,Castillo, Rafael
, p. 4615 - 4622 (2007/10/03)
Albendazole (Abz) and Mebendazole (Mbz) analogues have been synthesized and in vitro tested against the protozoa Giardia lamblia, Trichomonas vaginalis and the helminths Trichinella spiralis and Caenorhabditis elegans. Results indicate that compounds 4a, 4b (Abz analogues), 12b and 20 (Mbz analogues) are as active as antiprotozoal agents as Metronidazole against G. lamblia. Compound 9 was 58 times more active than Abz against T. vaginalis. Compounds 8 and 4a also shown high activity against this protozoan. Compounds 4b and 5a were as active as Abz. None of the Mbz analogues showed activity against T. vaginalis. The anthelmintic activity presented by these compounds was poor.
