56107-02-9

Usage

Uses

Used in Organic Synthesis:
4-Chloro-3-nitrobenzophenone is used as a starting material for the synthesis of various organic compounds. Its unique structural features, including the chlorine and nitro groups, make it a versatile building block for creating a wide range of molecules with different functional groups and applications across various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Chloro-3-nitrobenzophenone is used as an intermediate for the synthesis of various drugs and drug candidates. Its chemical properties allow for the development of molecules with potential therapeutic applications, such as antimicrobial, anti-inflammatory, and anticancer agents.
Used in Chemical Research:
4-Chloro-3-nitrobenzophenone is also utilized in chemical research for studying reaction mechanisms, exploring new synthetic routes, and developing novel methodologies in organic chemistry. Its reactivity and structural features make it an interesting subject for academic and industrial research.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 4-Chloro-3-nitrobenzophenone can be used as a precursor for the synthesis of various dyes and pigments with specific color properties. Its unique structure allows for the development of new colorants with improved performance characteristics, such as enhanced color strength, lightfastness, and stability.
Used in Material Science:
4-Chloro-3-nitrobenzophenone can be employed in the development of new materials with specific properties, such as photoactive materials, sensors, and advanced polymers. Its chemical properties can be exploited to create materials with unique optical, electronic, or mechanical characteristics for various applications in the material science field.

InChI:InChI=1/C13H8ClNO3/c14-11-7-6-10(8-12(11)15(17)18)13(16)9-4-2-1-3-5-9/h1-8H

Upstream product

• 38818-50-7 4-chloro-3-nitro-benzoyl chloride 
• 71-43-2 benzene 
• 100-58-3 phenylmagnesium bromide 
• 262357-37-9 4-chloro-3-nitro-benzoic acid methylamide 
• 74-11-3 para-chlorobenzoic acid 
• 106-43-4 para-chlorotoluene 
• 96-99-1 4-chloro-3-nitrobenzoate 

Downstream Products

• 82571-94-6 4-methoxy-3-nitro-benzophenone 
• 31431-19-3 2-nitro-4-benzoylaniline 
• 37567-44-5 3,3'-dinitro-4-chloro benzophenone 
• 861344-48-1 4'-chloro-2,3'-dinitro-benzophenone 
• 62261-38-5 (3-amino-4-chlorophenyl)phenylmethanone 
• 855195-45-8 4-(4-dimethylamino-anilino)-3-nitro-benzophenone 
• 111205-76-6 4-benzoyl-N,N-dimethyl-2-nitroaniline 
• 861377-50-6 4-anilino-3-nitro-benzophenone 
• 4413-46-1 (3-Oxy-benzo[1,2,5]oxadiazol-5-yl)-phenyl-methanone 
• 106851-18-7 (3-Nitro-4-trimethylsilanylethynyl-phenyl)-phenyl-methanone 
• 91713-64-3 diethyl 2-nitro-4-benzoylphenylmalonate 
• 66353-71-7 4-benzoyl-N-methyl-2-nitroaniline 
• 854020-53-4 3-amino-4-(4-dimethylamino-anilino)-benzophenone 
• 345581-75-1 1-{1-[2-Nitro-4-(phenylcarbonyl)phenyl]piperidin-4-yl}-1,4-dihydro-2H-3,1-benzoxazin-2-one 

Relevant academic research and scientific papers

Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage under Catalyst-Free Conditions

Conversion of a wide range of N-Boc amides to aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free conditions with different aryl, alkyl, and alkynyl Grignard reagents. α-Ketoamide was successfully converted to aryl diketones, while α,β-unsaturated amide underwent 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones. N-Boc amides displayed higher reactivity than Weinreb amides with Grignard reagents. A broad substrate scope, excellent yields, and quick conversion are important features of this methodology.

Synthetic method of 3-nitryl-4-chloro-benzophenone

The invention discloses a synthetic method of 3-nitryl-4-chloro-benzophenone. 3-nitryl-4-chlorobenzoic acid is converted into 3-nitryl-4-chloro-benzoyl chloride by selecting a new acylation reagent, and the 3-nitryl-4-chloro-benzoyl chloride and benzene perform Friedel-crafts reaction under the catalysis of Lewis acid to obtain the 3-nitryl-4-chloro-benzophenone. The method is simple in reaction path, easy to operate and suitable for large-scale production, and the middle process is easy to control.

MEBENDAZOLE POLYMORPH FOR TREATMENT AND PREVENTION OF TUMORS

Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. Three polymorphs of mebendazole exist, but the relative polymorph content for existing drugs varies, and the therapeutic anti-cancer relevance of the different polymorphs was unknown. As an oral drug mebendazole polymorph C is a superior form, and it reaches the brain and brain tumors in effective concentrations. Efficacy is further improved by combining mebendazole with a P-glycoprotein inhibitor. Mebendazole may also be used for therapy of other cancers, as well as a chemo-preventative agent.

Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides

The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.