66359-14-6

Basic information

• Product Name: N-hexylcinnamamide
• Synonyms: N-hexylcinnamamide
• CAS NO: 66359-14-6
• Molecular Weight: 231.338
• Mol File: 66359-14-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: N-hexylcinnamamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-hexylcinnamamide(66359-14-6)
• EPA Substance Registry System: N-hexylcinnamamide(66359-14-6)

Safety Data

• Hazardous Substances Data: 66359-14-6(Hazardous Substances Data)

Upstream product

• 111-26-2 hexan-1-amine 
• 103-41-3 (E)-cinnamic acid benzyl ester 
• 52392-64-0 (E)-3-(phenyl)acrylic acid butyl ester 
• 14990-09-1 tert-butyl cinnamate 
• 1866-31-5 (E)-allyl cinnamate 
• 140-10-3 (E)-3-phenylacrylic acid 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 103-26-4 Methyl cinnamate 
• 621-82-9 Cinnamic acid 
• 104-54-1 3-Phenylpropenol 
• 103-26-4 methyl cinnamate 
• 103-64-0 bromostyrene 
• 13939-06-5 molybdenum hexacarbonyl 

Relevant articles and documents

Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi

Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new drugs have been approved for this disease in the last 60 years. Molecular modifications based on

Zirconium Oxide-Catalyzed Direct Amidation of Unactivated Esters under Continuous-Flow Conditions

A sustainable and environmentally benign direct amidation reaction of unactivated esters with amines has been developed in a continuous-flow system. A commercially available amorphous zirconium oxide was found to be an efficient catalyst for this reaction. While the typical amidation of esters with amines requires a stoichiometric amount of a promoter or metal activator, the present continuous-flow method enabled the direct amidation reaction under additive-free conditions with an extensive diversity towards various functional groups. High yields of the products were obtained with a nearly equimolar proportion of starting materials to reduce byproduct formation, which renders this process applicable for use in a sequential-flow system. (Figure presented.).

Enhancing Ligand-Free Fe-Catalyzed Aminocarbonylation of Alkynes by ZrF4

Zirconium fluoride was utilized to promote efficiently iron-catalyzed aminocarbonylation between alkynes and amines without the use of extra ligands. In particular, this new system is applicable to a wide range of amine and alkyne substrates affording α,β-unsaturated amides in good to excellent yields. Preliminary mechanistic studies reveal the activation model involving interactions of ZF4 with both iron catalyst and amine substrates.