6636-02-8

Basic information

• Product Name: 2,2-DIPHENYLACETOHYDRAZIDE
• Synonyms: 2,2-DIPHENYLACETOHYDRAZIDE;2,2-diphenylacetohydrazide(SALTDATA: FREE);Benzeneacetic acid, a-phenyl-, hydrazide;2,2-di(phenyl)ethanehydrazide
• CAS NO: 6636-02-8
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.27376
• Mol File: 6636-02-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 449.6°C at 760 mmHg
• Flash Point: 225.7°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 2.82E-08mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 2,2-DIPHENYLACETOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIPHENYLACETOHYDRAZIDE(6636-02-8)
• EPA Substance Registry System: 2,2-DIPHENYLACETOHYDRAZIDE(6636-02-8)

Safety Data

• Hazardous Substances Data: 6636-02-8(Hazardous Substances Data)

Usage

General Description

2,2-DIPHENYLACETOHYDRAZIDE, also known as Dibenzalacetone hydrazone, is a chemical compound widely used as a reagent in organic chemistry. It is a yellow crystalline solid with a molecular formula of C16H16N2O. It has applications in the synthesis of pharmaceuticals, dyes, and rubber chemicals. 2,2-DIPHENYLACETOHYDRAZIDE is also used as a UV stabilizer and as an intermediate in the production of various other compounds. It is important to handle this chemical with care as it can be harmful if ingested, inhaled, or comes into contact with skin or eyes.

InChI:InChI=1/C14H14N2O/c15-16-14(17)13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,13H,15H2,(H,16,17)

Upstream product

• 3468-99-3 ethyl diphenylacetate 
• 7803-57-8 hydrazine hydrate 
• 117-34-0 2,2-diphenylacetic acid 
• 1856-33-3 5-benzhydryl-1H-1,2,3,4-tetrazole 
• 86-29-3 Diphenylacetonitrile 
• 3469-00-9 methyl 2,2-diphenylacetate 
• 1871-76-7 diphenylacetic acid chloride 
• 57301-63-0 2-<1'-(Diphenylacetoxy)-2',2'-diphenylethenyl>-1-methyl-benzimidazole 

Downstream Products

• 38084-23-0 N,N'-bis-diphenylacetyl-hydrazine 
• 1276682-33-7 5-(diphenylmethyl)-2-(4-chlorophenyl)amino-1,3,4-oxadiazole 
• 1276682-34-8 5-(diphenylmethyl)-N-(4-fluorophenyl)-1,3,4-oxadiazol-2-amine 
• 1276682-35-9 5-(diphenylmethyl)-N-(3-chloro-4-fluorophenyl)-1,3,4-oxadiazol-2-amine 
• 1276682-36-0 5-(diphenylmethyl)-2-(4-methylphenyl)amino-1,3,4-oxadiazole 
• 1276682-38-2 5-(diphenylmethyl)-4-(4-chlorophenyl)-3-mercapto-(4H)-1,2,4-triazole 
• 1276682-39-3 5-(diphenylmethyl)-4-(4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole 
• 1276682-40-6 5-(diphenylmethyl)-4-(3-chloro-4-fluorophenyl)-3-mercapto-(4H)-1,2,4-triazole 
• 1276682-41-7 5-(diphenylmethyl)-4-(4-methylphenyl)-3-mercapto-(4H)-1,2,4-triazole 
• 1276682-43-9 5-(diphenylmethyl)-2-(4-chlorophenyl)amino-1,3,4-thiadiazole 
• 1276682-44-0 5-(diphenylmethyl)-2-(4-fluorophenyl)amino-1,3,4-thiadiazole 
• 1276682-45-1 5-(diphenylmethyl)-2-(3-chloro-4-fluorophenyl)amino-1,3,4-thiadiazole 
• 1276682-46-2 5-(diphenylmethyl)-2-(4-methylphenyl)amino-1,3,4-thiadiazole 
• 1276682-37-1 5-(diphenylmethyl)-2-(4-methoxyphenyl)amino-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis and biological evaluation of some new furoxan derivatives as anti-inflammatory agents

A new series of furoxan derivatives (3a-k) have been synthesized and characterized by their IR, 1H NMR and mass spectral data. All the compounds have been screened for their anti-inflammatory activity. The compounds 3a, 3b, 3f, 3g, and 3i which show significant anti-inflammatory activity have been further studied for their ulcerogenic activities and nitric oxide releasing properties. Furoxan derivative 3-memyl-4-[{2-(2-phenylacetyl)hydrazono}memyl]-furoxan 3f showed greater anti-inflammatory activity comparable to standard drug ibuprofen. The compound also showed reduced, ulcerogenicity and high nitric oxide releasing properties.

Design, synthesis and pharmacological evaluation of novel azole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents

A series of substituted azole derivatives (3a-e, 4a-e and 5a-e) were synthesised by the cyclisation of N1(diphenylethanoyl)-N 4-substituted phenyl thiosemicarbazides under various reaction conditions. These compounds were tested in v

New potent inhibitors of tyrosinase: Novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site

A series of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides were tailored and synthesized as new potent inhibitors of tyrosinase. The rationale for inhibitor design was based on the active site structural evidence from the crystal structures of bacterial tyrosinase and potato catechol oxidase enzymes. Kinetic and active site binding studies suggested mono-dentate binding of thiadiazole, oxadiazole, and triazole rings to the active site dicopper center of tyrosinase including hydrophobicity contributing to the potent inhibition. Kinetic plots showed mixed-type of inhibition by all 25 compounds. Substitutions at C3 of the triazole ring and C5 of the thiadiazole/oxadiazole rings were found to be playing a major role in the high binding affinity to tyrosinase. The current work may help develop new potent tyrosinase inhibitors against hyperpigmentation including potential insecticides.