6636-80-2Relevant academic research and scientific papers
Continuous flow synthesis of ketones from carbon dioxide and organolithium or grignard reagents
Wu, Jie,Yang, Xiaoqing,He, Zhi,Mao, Xianwen,Hatton, T. Alan,Jamison, Timothy F.
supporting information, p. 8416 - 8420 (2014/08/18)
We describe an efficient continuous flow synthesis of ketones from CO 2 and organolithium or Grignard reagents that exhibits significant advantages over conventional batch conditions in suppressing undesired symmetric ketone and tertiary alcohol byproducts. We observed an unprecedented solvent-dependence of the organolithium reactivity, the key factor in governing selectivity during the flow process. A facile, telescoped three-step-one-flow process for the preparation of ketones in a modular fashion through the in-line generation of organometallic reagents is also established.
Salt effects on the reactivity and the stability of organomanganese reagents
Cahiez, Gerard,Razafintsalama, Lynah,Laboue, Blandine,Chau, Francois
, p. 849 - 852 (2007/10/03)
The reactivity and the stability of organomanganese reagents prepared from the ate complexes MnX2·2LiBr (X= Br,I) and MnCl2·R4NX (X= Br, Cl) were studied. The preparation and the use for synthetic applications of stable sec- and tert-alkylmanganese bromides in ether as well as the acylation of RMnCl by R'COOCOOEt in THF were successfully achieved for the first time.
N-Arylsulfonylamidines; Part 2. A New Synthesis of Ketones from N'-Tosylamidines and Organolithium Compounds
Clerici, Francesca,Gelmi, Maria Luisa,Rossi, Luisa Maria
, p. 1025 - 1027 (2007/10/02)
Tertiary N'-arylsulfonylamidines readily react with organolithium compounds under simple conditions to afford carbonyl compounds.
