663606-12-0

Basic information

• Product Name: Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester
• Synonyms: Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester
• CAS NO: 663606-12-0
• Molecular Weight: 725.126
• Mol File: 663606-12-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester(663606-12-0)
• EPA Substance Registry System: Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester(663606-12-0)

Safety Data

• Hazardous Substances Data: 663606-12-0(Hazardous Substances Data)

Upstream product

• 2244-16-8 (S)-p-mentha-6,8-dien-2-one 
• 663605-86-5 tert-Butyl-[(1S,2R,3S,4S)-4-isopropenyl-3-(4-methoxy-benzyloxymethyl)-2-methyl-cyclopentyloxy]-diphenyl-silane 
• 663605-87-6 1-[(1S,2R,3R,4S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methyl-cyclopentyl]-ethanone 
• 663605-85-4 (1S,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-isopropenyl-2-methyl-cyclopentanecarboxylic acid methyl ester 
• 950849-05-5 [(1S,2R,3S,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-isopropenyl-2-methyl-cyclopentyl]-methanol 
• 663606-09-5 methyl (1S,2R,3S,5S)-3-hydroxy-5-isopropenyl-2-methylcyclopentanecarboxylate 
• 156629-27-5 (2R,3S,5S)-2-Chloro-5-isopropenyl-2-methyl-3-(tetrahydro-pyran-2-yloxy)-cyclohexanone 
• 156714-42-0 (1S,2R,3S,5S)-5-Isopropenyl-2-methyl-3-(tetrahydro-pyran-2-yloxy)-cyclopentanecarboxylic acid methyl ester 
• 156714-47-5 (2R,3S,5S)-2-Chloro-3-hydroxy-5-isopropenyl-2-methyl-cyclohexanone 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 672898-50-9 (S)-carvone epoxide 
• 663605-94-5 (4S,4aR,5R,6S,7aS,8S,9aS)-6-(tert-Butyl-diphenyl-silanyloxy)-8-methoxymethoxy-3,5,8-trimethyl-4-triethylsilanyloxy-4a,5,6,7,7a,8,9,9a-octahydro-4H-azuleno[6,5-b]furan-2-one 
• 663605-91-2 C₄₀H₆₄O₅Si₂ 
• 663605-93-4 (2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-5-one 

Downstream Products

• 50657-07-3 trilobolide 
• 136051-63-3 nortrilobolide 
• 663606-00-6 (2aS,5aS,7S,7aS,9S,10R,10aR,10bS,10cR)-9-(tert-Butyl-diphenyl-silanyloxy)-7,10c-dihydroxy-2a,4,4,7,10-pentamethyl-decahydro-1,3,5-trioxa-benzo[cd]cyclopenta[h]azulen-2-one 
• 663605-99-0 (3S,3aR,4S,6S,6aS,8S,9R,9aR,9bS)-8-(tert-Butyl-diphenyl-silanyloxy)-3,3a-dihydroxy-4,6-bis-methoxymethoxy-3,6,9-trimethyl-decahydro-azuleno[4,5-b]furan-2-one 
• 663605-98-9 (2S,3R,3aR,4S,5S,6S,8S,8aS)-2-(tert-Butyl-diphenyl-silanyloxy)-5-((R)-1,2-dihydroxy-1-methyl-ethyl)-6,8-bis-methoxymethoxy-3,8-dimethyl-decahydro-azulene-4,5-diol 
• 663605-97-8 Acetic acid (R)-2-[(2S,3R,3aR,4S,5R,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-6,8-bis-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-decahydro-azulen-5-yl]-2-hydroxy-propyl ester 
• 663605-96-7 Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6,8-bis-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester 

Relevant articles and documents

Total synthesis of five thapsigargins: Guaianolide natural products exhibiting sub-nanomolar SERCA inhibition

Herein we describe the total synthesis of five guaianolide natural products: thapsigargin. thapsivillosin C, thapsivillosin F, trilobolide and nortrilobolide. Prodrug derivatives of thapsigargin have shown selective in vivo cytotoxicity against prostate tumours and the need for further investigation of this phenomenon highlights the importance of these total syntheses. The first absolute stereochemical assignment of thapsivillosin C is also delineated.