Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester

Base Information

Chemical Name:Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester
CAS No.:663606-12-0
Molecular Formula:C₄₁H₆₄O₇Si₂
Molecular Weight:725.126
Hs Code.:

Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester

Synonyms:Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester

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Chemical Property of Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester

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Technology Process of Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester

There total 23 articles about Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-24-7
acetic anhydride

: 663605-95-6
(1R,2S,3aS,4S,6S,8S,8aR)-2-(tert-Butyl-diphenyl-silanyloxy)-7-[2-hydroxy-1-methyl-eth-(E)-ylidene]-4-methoxymethoxy-1,4-dimethyl-8-triethylsilanyloxy-decahydro-azulen-6-ol

: 663606-12-0
Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester

Guidance literature:: With 2,6-dimethylpyridine; dmap; In dichloromethane; at 20 ℃;
DOI:10.1002/anie.200353140

Reference yield:

: 663605-91-2
C₄₀H₆₄O₅Si₂

: 663606-12-0
Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Grubbs' dihydroimidazoline ruthenium catalyst / dichloromethane / Heating

2: potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium hexacyanoferrate(III) / methanesulfonamide; potassium carbonate / tert-butyl alcohol / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4: sodium hydride / tetrahydrofuran / Heating

5: lithium borohydride / tetrahydrofuran / Heating

6: 2,6-dimethylpyridine; dmap / dichloromethane / 20 °C

With 2,6-dimethylpyridine; dmap; lithium borohydride; potassium dioxotetrahydroxoosmate(VI); sodium hydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hexacyanoferrate(III); methanesulfonamide; Grubbs' dihydroimidazoline ruthenium catalyst; potassium carbonate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 4: Horner-Wadsworth-Emmons reaction;
DOI:10.1002/anie.200353140

Reference yield:

: 663605-92-3
(1R,2S,3aS,4S,8S,8aR)-2-(tert-Butyl-diphenyl-silanyloxy)-7-ethoxy-4-methoxymethoxy-1,4-dimethyl-8-triethylsilanyloxy-1,2,3,3a,4,5,8,8a-octahydro-azulene

: 663606-12-0
Acetic acid 2-[(2S,3R,3aR,4S,6S,8S,8aS)-2-(tert-butyl-diphenyl-silanyloxy)-6-hydroxy-8-methoxymethoxy-3,8-dimethyl-4-triethylsilanyloxy-octahydro-azulen-(5E)-ylidene]-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium dioxotetrahydroxoosmate(VI); sodium hydrogencarbonate; potassium hexacyanoferrate(III) / methanesulfonamide; potassium carbonate / tert-butyl alcohol / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3: sodium hydride / tetrahydrofuran / Heating

4: lithium borohydride / tetrahydrofuran / Heating

5: 2,6-dimethylpyridine; dmap / dichloromethane / 20 °C

With 2,6-dimethylpyridine; dmap; lithium borohydride; potassium dioxotetrahydroxoosmate(VI); sodium hydride; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hexacyanoferrate(III); methanesulfonamide; potassium carbonate; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 3: Horner-Wadsworth-Emmons reaction;
DOI:10.1002/anie.200353140