66364-50-9Relevant academic research and scientific papers
Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors
Aoyama, Yasunori,Uenaka, Masaaki,Konoike, Toshiro,Iso, Yasuyoshi,Nishitani, Yasuhiro,Kanda, Akiko,Naya, Noriyuki,Nakajima, Masatoshi
, p. 2397 - 2401 (2007/10/03)
1-Oxacephem derivatives were synthesized and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 1-oxacephems led to compound 34, which exhibited 6 nM inhibition of human chymase and high selectivity for human chymase compared to other serine enzymes. (C) 2000 Elsevier Science Ltd.
Synthesis and 3'-Substituent Effects of Some 7α-Methoxy-1-oxacephems on Antibacterial Activity and Alkaline Hydrolysis Rates
Narisada, Masayuki,Nishikawa, Junko,Watanabe, Fumihiko,Terui, Yoshihiro
, p. 514 - 522 (2007/10/02)
Relationships between intrinsic antibacterial activity and β-lactam chemical reactivity of 7β-(phenylacetamido)-7α-methoxy-1-oxacephems with various 3'-substituents (1-9) were studied in order to clarify the effect of the 3'-substituent on the antibacteri
