6637-11-2

Basic information

• Product Name: 2,3'-Bi-1H-indole,2,3-dihydro-1,1'-dimethyl-
• Synonyms: 2,3'-Biindole,2,3-dihydro-1,1'-dimethyl- (8CI); Indoline, 1-methyl-2-(1-methylindol-3-yl)-(7CI); 1-Methyl-3-(1-methyl-2,3-dihydro-1H-indol-2-yl)-1H-indole; NSC 52362
• CAS NO: 6637-11-2
• Molecular Formula: C18H18 N2
• Molecular Weight: 262.354
• Mol File: 6637-11-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,3'-Bi-1H-indole,2,3-dihydro-1,1'-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3'-Bi-1H-indole,2,3-dihydro-1,1'-dimethyl-(6637-11-2)
• EPA Substance Registry System: 2,3'-Bi-1H-indole,2,3-dihydro-1,1'-dimethyl-(6637-11-2)

Safety Data

• Hazardous Substances Data: 6637-11-2(Hazardous Substances Data)

Usage

Indole derivative

A modified version of the parent compound indole.

Methyl groups

Two methyl groups attached at the 1 and 1' positions.

Chemical properties

Not well-studied, but may have potential applications.

Pharmaceutical industry

Possible use in the synthesis of new drugs.

Organic synthesis

May serve as a building block for creating other chemical compounds.

Further research

Necessary to fully understand the properties and potential uses of this compound.

Upstream product

• 603-76-9 1-methylindole 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1415328-91-4 1-methyl-3-[(4-methylphenyl)sulfanyl]-1H-indole 
• 41600-21-9 methyl 2-oxo-2-(pyrrolidin-1-yl)acetate 
• 13157-96-5 methyl 2-chloro-2-methoxyacetate 

Downstream Products

• 1160710-48-4 4-(1-benzyl-1H-indol-3-yl)-4-bis(1-methyl-1H-indol-3-yl)but-3-en-2-one 

Relevant articles and documents

Switchable regioselection of C-H thiolation of indoles using different TMS counterions

A switchable regioselectivity in C-H thiolation reaction by simply swapping the counteranions of TMS is reported here for the first time. An exclusive C3-H thiolation of indoles with sodium arylsulfinates was achieved in the presence of TMSCl as a promoter. In contrast, with the use of TMSOTf instead of TMSCl under otherwise identical conditions, a regiospecific C2-H thiolation of indoles was realized with the same set of substrates.

Vilsmeier Formylation and Glyoxylation Reactions of Nucleophilic Aromatic Compounds Using Pyrophosphoryl Chloride

Reactions of N,N-dimethylformamide and N-methylformanilide with pyrophosphoryl chloride lead to the formation of reagents that undergo reactions with a wide range of nucleophilic aromatic substrates, including indoles, pyrroles, thiophenes, furans, and methoxy-substituted carbocyclic arenes to afford, after hydrolysis of the initial products, good to excellent yields of the expected aldehydes; reactions with methyl oxamates allow the preparation of methyl arylglyoxylates. Key words: pyrophosphoryl chloride, N,N-dimethylformamide, methoxyarene, heterocyle, formylation