6637-12-3

Usage

Uses

Used in Pharmaceutical Industry:
Diethyl [(2-methyl-1H-indol-3-yl)methyl]propanedioate is used as a chemical intermediate for the synthesis of various pharmaceutical drugs. Its unique structure and reactivity allow for the creation of new drug molecules with potential therapeutic applications.
Used in Chemical Industry:
In the chemical industry, diethyl [(2-methyl-1H-indol-3-yl)methyl]propanedioate serves as a key component in the production of other organic compounds. Its versatility in chemical reactions enables the development of novel chemical entities for various applications.

Upstream product

• 37125-92-1 2-methylgramine 
• 105-53-3 diethyl malonate 
• 95-20-5 2-methyl-1H-indole 

Relevant academic research and scientific papers

5-(Cyano)dibenzothiophenium Triflate: A Sulfur-Based Reagent for Electrophilic Cyanation and Cyanocyclizations

The synthesis of 5-(cyano)dibenzothiophenium triflate 9, prepared by activation of dibenzo[b,d]thiophene-5-oxide with Tf2O and subsequent reaction with TMSCN is reported, and its reactivity as electrophilic cyanation reagent evaluated. The scalable preparation, easy handling and broad substrate scope of the electrophilic cyanation promoted by 9, which includes amines, thiols, silyl enol ethers, alkenes, electron rich (hetero)arenes and polyaromatic hydrocarbons, illustrate the synthetic potential of this reagent. Importantly, Lewis acid activation of the reagent is not required for the transfer process. We additionally report herein biomimetic cyanocyclization cascade reactions, which are not promoted by typical electrophilic cyanation reagents, demonstrating the superior ability of 9 to trigger challenging transformations.