66373-63-5

Upstream product

• 93634-54-9 (Z)-2-methyl-4-(4-methylbenzylidene)oxazol-5(4H)-one 
• 5805-39-0 2-(aminophenyl)benzimidazole 
• 38879-46-8 (Z)-4-benzylidene-2-methyl-5(4H)-oxazolone 
• 71198-72-6 (4Z)-4-(4-methoxybenzylidene)-2-methyl-oxazolin-5-one 
• 57731-07-4 4-(3-nitrobenzylidene)-2-methyloxazoline-5-one 
• 93634-55-0 (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one 
• 248257-00-3 1-acetyl-2-(2-nitrophenyl)benzimidazol 

Downstream Products

• 5805-39-0 2-(aminophenyl)benzimidazole 

Relevant academic research and scientific papers

Azlactones in heterocyclic synthesis: Part IV - A new route for the synthesis of 6-substituted and 6-arylidene-benzimidazo-[1,2-c]quinazolines

Condensation of 2-(o-aminophenyl) benzimidazole 1 with 4- arylidene-2-substituted oxazolin-5-ones 2 (azlactones) in acetic acid results in the formation of 5,6-dihydro-6-arylidene-benzimidazo[1,2-c]quinazolines 3 and 6-substituted benzimidazo[1,2-c]quinazolines 4. Structures of these compounds have been established based on their spectral data, and direct comparison with authentic samples prepared by unambiguous routes.

Access to quinazolines from 2-nitrobenzaldehyde and arylamines

A synthesis of N-(2-nitrobenzyl)acetanilide (5) and (11) from 2- nitrobenzaldehyde and aromatic amines is reported. The reaction of amides (5) and (11) with iron in acetic acid-ethanol-water provided the corresponding 3- phenyl-π-1,2,3,4-tetrahydroquinazo