6638-11-5Relevant academic research and scientific papers
An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives
Mathew, Bijoy P.,Kumar, Awanit,Sharma, Satyasheel,Shukla,Nath, Mahendra
experimental part, p. 1502 - 1507 (2010/06/14)
A series of 3,4-dihydro-2H-benzo[e]-, 2,3-dihydro-1H-naphtho[1,2-e]-, 3,4-dihydro-2H-naphtho[2,1-e][1,3]oxazine and 1,2-bis(3,4-dihydrobenzo[e][1,3]oxazin-3(4H)-yl)ethane derivatives was obtained through an eco-friendly Mannich type condensation-cyclization reaction of phenols or naphthols with formaldehyde and primary amines in water at ambient temperature. Preliminary in vitro antimicrobial activity of the synthesized compounds was assessed against six pathogenic fungi, two Gram-negative and two Gram-positive bacteria. Some of the screened compounds have shown significant in vitro antimicrobial effect. Cytotoxic activities of the lead compounds (2m, 2n, 3c and 3d) against mouse fibroblast cell line (L929) were determined by MTT method. The assay results revealed that these molecules offered remarkable viability (>90%) of L929 cells at concentration of 25?μg/mL.
One-pot three-component synthesis of dihydrobenzo- and naphtho[e]-1,3- oxazines in water
Mathew, Bijoy P.,Nath, Mahendra
experimental part, p. 1003 - 1006 (2009/12/06)
(Chemical Equation Presented) A simple, green and efficient method has been developed for the synthesis of biologically and materially important dihydrobenzo/naphtho[e]-1,3-oxazines in good to excellent yields through a Mannich-type condensation cyclizati
NOUVELLE VOIE D'ACCES AUX DIHYDRO-3,4-2H-BENZOXAZINES-1,3
Colin, J. L.,Loubinoux, B.
, p. 4245 - 4246 (2007/10/02)
3,4-Dihydro-2H-1,3-benzoxazines were prepared from primary amines and dihalocompounds by a method which can lead to compounds dissymetrically substituted in positions 2 and 4.
