6638-24-0

Usage

Chemical structure

A complex structure containing a naphthalene ring, a substituted phenylamino group, and a methoxy group.

Functional groups

Hydroxyl group at the 2-position, amino group, and methoxy group.

Amino group attachment

Directly bonded to a methylene group, which is connected to the naphthalene ring.

Potential applications

Pharmaceutical industry, dyes, and other industries.

Organic synthesis

The presence of amino and hydroxyl groups makes it useful for organic synthesis and drug development.

Research and testing

Further research and testing are needed to fully understand its properties and potential uses.

Upstream product

• 135-19-3 β-naphthol 
• 433954-83-7 2-(tert-butyldimethylsilyloxy)naphthalene-1-carbaldehyde 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 1354018-46-4 (2-[(tert-butyldimethylsilyl)oxy]-1-naphthyl)methyl nitrate 
• 104-94-9 4-methoxy-aniline 
• 1354018-42-0 {2-[(tert-butyldimethylsilyl)oxy]naphthalen-1-yl}methanol 
• 50-00-0 formaldehyd 
• 32752-37-7 1,3,5-tris(4-methoxyphenyl)-1,3,5-triazinane 

Downstream Products

• 1096-84-0 bis(2-hydroxy-1-naphthyl)methane 

Relevant academic research and scientific papers

Mild and rapid method for the generation of ortho -(naphtho)quinone methide intermediates

A new mild method has been devised for generating o-(naphtho)quinone methides via fluoride-induced desilylation of silyl derivatives of o-hydroxybenzyl(or 1-naphthylmethyl) nitrate. The reactive o-(naphtho)quinone methide intermediates were trapped by C,

Iminium Salts in Solid-State Syntheses Giving 100% Yield

Numerous reaction types in the field of iminium salts are performed in the gas-solid and solid-solid techniques in order to reach 100% yield. The stoichiometric runs are waste-free and do not require costly workup. Frequently, iminium salts were avoided, as acid catalysis was dispensable. Thioureas and α-halogenated ketones give a variety of 2-aminothiazoles via thiuronium salts in quantitative yield. A new intramolecular solid-state thermal condensation is reported. Enaminoketones are synthesized quantitatively from anilines and 1,3-diketones without catalysis and those can be used for quantitative solid-state 4-cascade reactions. Solid paraformaldehyde is used to produce methylene imines and internally trapped methylene iminium salts. Benzoylhydrazones are produced again without catalysis in the solid state. Vacuum and ball-mill techniques are particularly useful in the production of highly sensitive iminium salts. Hexahydro-1,3,5-triazines cyclorevert upon exposure to HCl gas to give solid arylmethylene iminium chlorides as new versatile reagents. These are used in arylaminomethylations of β-naphthol and of themselves to give Troeger's bases in 3-cascades. More direct are 4-cascade Troeger's base syntheses by dissolving hexahydro-1,3,5-triaryltriazines in trifluoroacetic acid. Alkylations of imines with trimethyloxonium tetrafluoroborate and triphenylmethyl cation give highly sensitive quaternary iminium salts in the ball-mill. The products are characterized by spectroscopic techniques and density functional theory (DFT) calculations at the B3LYP 6-31G* level. Molecular movements in the crystal and surface passivation are investigated with atomic force microscopy (AFM) techniques.

Heterocyclic spirocyclohexadienones, II

Hofmann-Martius rearrangement of differently substituted aniline derivatives is investigated and the synthesis of spirocyclohexadienones 5 and 25 is performed. In comparison with 9, a N-aliphatic spiro compound, 5 and 25 give partially different reactions, the cause of which is discussed.