663923-72-6Relevant academic research and scientific papers
Oxidative amidation of benzyl alcohols with amino acid esters mediated by N-hydroxysuccinimide/phenyliodine diacetate
Mahesh, Mandipogula,Panduranga, Veladi,Prabhu, Girish,Kumar L, Roopesh,Ramana, P. Venkata,Sureshbabu, Vommina V.
, p. 716 - 721 (2017/03/27)
A simple protocol involving metal-free oxidative amidation of benzyl alcohols with amino acid esters has been presented. The amidation proceeds in a radical pathway unlike in conventional metal-mediated extrusion of dihydrogen. The method is advantageous in terms of metal-free conditions, nonexpensive commercial starting substrates. Also various substituents in the starting materials are tolerated and sterically hindered amino acid side chains could provide good yields of amide products.
New cyanopeptide-derived low molecular weight inhibitors of trypsin-like serine proteases
Radau, Gregor,Schermuly, Sonja,Fritsche, Alexandra
, p. 300 - 309 (2007/10/03)
This paper deals with the design, syntheses, and inhibition tests of new low molecular weight thrombin inhibitors utilizing cyanopeptides, the secondary metabolites of cyanobacteria with interesting biological activities, as new lead structures. Starting with aeruginosin 98-B (1) as a lead structure, we have developed and synthesised new, selective acting inhibitors of serine proteases (RA-1005 and RA-1009), which are suitable targets for further structure-activity studies.
