66394-73-8

Basic information

• Product Name: (18α,19α)-16-Hydroxyurs-20-en-3-one
• Synonyms: (18α,19α)-16-Hydroxyurs-20-en-3-one
• CAS NO: 66394-73-8
• Molecular Formula: C30H48O2
• Molecular Weight: 440.70092
• Mol File: 66394-73-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (18α,19α)-16-Hydroxyurs-20-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (18α,19α)-16-Hydroxyurs-20-en-3-one(66394-73-8)
• EPA Substance Registry System: (18α,19α)-16-Hydroxyurs-20-en-3-one(66394-73-8)

Safety Data

• Hazardous Substances Data: 66394-73-8(Hazardous Substances Data)

Upstream product

• 20554-95-4 faradiol 

Downstream Products

• 66394-76-1 16-Oxo-ψ-taraxen 
• 66394-77-2 16α-Hydroxy-ψ-taraxen 
• 66394-74-9 16β-Hydroxy-ψ-taraxen 

Relevant articles and documents

Cytotoxic and Apoptosis-inducing Activities of Taraxastane-type Triterpenoid Derivatives in Human Cancer Cell Lines

Twenty-eight taraxastane-type triterpenoid derivatives 4?–?31 were prepared from the naturally occurring triterpenoids faradiol (1) and heliantriol C (3). The cytotoxic activities of these compounds and arnidiol (2) were evaluated in leukemia (HL60), lung (A549), duodenal (AZ521), and breast (SK-BR-3) cancer cell lines. 21-Oxoarnidiol (18) and faradiol 3,16-di-O-l-alaninate (31) exhibited potent cytotoxicity, with 50% inhibitory concentrations of 0.5?–?2.7?μm. In particular, flow cytometric analysis indicated that compound 31 induced typical apoptotic cell death in HL60 cells. These results suggested that taraxastane-type triterpenoid derivatives might provide useful antitumor agents with apoptosis-inducing activity.