66399-73-3Relevant academic research and scientific papers
Domino Hydrogenation-Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylamines
Jumde, Varsha R.,Petricci, Elena,Petrucci, Chiara,Santillo, Niccol,Taddei, Maurizio,Vaccaro, Luigi
, p. 3990 - 3993 (2015)
Phenols can be efficiently reduced by sodium formate and Pd/C as the catalyst in water and in the presence of amines to give the corresponding cyclohexylamines. This reaction works at rt for 12 h or at 60 °C under microwave dielectric heating for 20 min. With the exception of aniline, primary, secondary amines, amino alcohols, and even amino acids can be used as nucleophiles. The reductive process is based on a sustainable hydrogen source and a catalyst that can be efficiently recovered and reused. The protocol was developed into a continuous-flow production of cyclohexylamines in gram scale achieving very efficient preliminary results (TON 32.7 and TOF 5.45 h-1).
Studies on the reduction and reductive alkylation of amino acid-derived spirocyclic 2,6-dioxopiperazines
González-Vera, Juan A.,Ventosa-Andrés, Pilar,Casey, Joanne,García-López, M. Teresa,Herranz, Rosario
, p. 2675 - 2683 (2007)
The regio- and diastereoselective reduction and reductive alkylation of 3-spiro-2,6-dioxopiperazines are described via a two-step process, which involves addition of NaBH4 or Grignard reagents, followed by TFA-mediated dehydration with a second
Sterically encumbered chiral amino alcohols for titanium-catalyzed asymmetric intramolecular hydroamination of aminoallenes
Hickman, Amanda J.,Hughs, Lauren D.,Jones, Casey M.,Li, Hanhan,Redford, Joanne E.,Sobelman, Samuel J.,Kouzelos, J. Andrew,Johnson, Adam. R.
body text, p. 1279 - 1285 (2009/10/17)
A variety of sterically encumbered amino alcohol ligands were prepared in a two-step modular synthesis. The titanium complexes of these ligands were prepared in situ and used as catalysts for hydroamination. The intramolecular hydroamination of 6-methyl-h
