6640-08-0 Usage
General Description
1-(2-methylpropyl)dihydropyrimidine-2,4(1H,3H)-dione, also known as brequinar, is a chemical compound primarily used as an immunosuppressive drug. It works by inhibiting the enzyme dihydroorotate dehydrogenase, which is involved in the de novo pyrimidine synthesis pathway. This inhibition ultimately leads to the suppression of T-cell activation and proliferation, making it a useful drug for preventing transplant rejection and treating autoimmune diseases. Brequinar has also been studied for its potential anti-cancer properties, as the de novo pyrimidine synthesis pathway is often upregulated in cancer cells. However, further research is needed to fully understand its anticancer effects and potential use in cancer therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 6640-08-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,4 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6640-08:
(6*6)+(5*6)+(4*4)+(3*0)+(2*0)+(1*8)=90
90 % 10 = 0
So 6640-08-0 is a valid CAS Registry Number.
6640-08-0Relevant articles and documents
Improved synthesis of N1-substituted orotic acid derivatives
Senger, Nicholas A.,Bowler, Jeannette T.,Mercado, Rene S.,Lin, Sidney,Wu, Weiming
, p. 4245 - 4246 (2013/07/26)
An improved method for the synthesis of N1-substituted orotic acid derivatives is reported. The method involves sequential incorporation of nitrogen atoms to the pyrimidine structure from simple starting materials and thus allows the synthesis of N1-subst