6640-22-8

Basic information

• Product Name: 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt
• Synonyms: PAMOIC ACID DISODIUM SALT 98+%;DisodiumPamoate98%;DISODIUMEMBONATE;4,4μ-Methylenebis(3-hydroxy-2-naphthoic acid), Embonic acid, Sodium pamoate;2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, disodium salt;Disodium 4-[(3-carboxylato-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate;1,1'-Methylenebis(2-hydroxy-3-naphthalenecarboxylic acid sodium) salt;1,1'-Methylenebis(2-hydroxy-3-naphthalenecarboxylic acid)disodium salt
• CAS NO: 6640-22-8
• Molecular Formula: C₂₃H₁₄O₆*2Na
• Molecular Weight: 432.33
• EINECS: 229-653-1
• Mol File: 6640-22-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 300 °C
• Boiling Point: 642.7 °C at 760 mmHg
• Flash Point: 356.5 °C
• Appearance: /solid
• Density: 1.55[at 20℃]
• Vapor Pressure: 2.13E-17mmHg at 25°C
• Solubility: insoluble in EtOH; ≥18 mg/mL in H2O; ≥28.6 mg/mL in DMSO
• Water Solubility: 43g/L at 20℃
• CAS DataBase Reference: 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt(6640-22-8)
• EPA Substance Registry System: 4,4'-Methylenebis(3-hydroxy-2-naphthoic acid) disodium salt(6640-22-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-37/38-41-48
• Safety Statements: 24/25-45-36/37/39-26-22
• WGK Germany: 3
• Hazardous Substances Data: 6640-22-8(Hazardous Substances Data)

Usage

Uses

Pamoic acid disodium salt, a supposedly inactive component in many formulations of drugs used to modulate release, is a potent agonist of the orphan receptor GPR35. GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR), strongly expressed in the lower intestine and colon, dorsal root ganglia, as well as a variety of immune cells including monocytes and dendritic cells. Targeting GPR35 provides potential therapeutic opportunities in a range of conditions, such as inflammation, pain and cancer.

Flammability and Explosibility

Notclassified

Biological Activity

Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.

InChI:InChI=1/C23H16O6.2Na/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;;/h1-10,24-25H,11H2,(H,26,27)(H,28,29);;/q;2*+1/p-2

Upstream product

• 130-85-8 Pamoic acid 

Downstream Products

• 3546-41-6 pyrvinium pamoate 
• 1417425-02-5 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine monopamoate 
• 10075-24-8 imipramine pamoate 

Relevant articles and documents

Stabilisation of pharmacologically active compounds in sustained release compositions

A pharmaceutical composition comprising as the active agent a peptide in association with embonic acid or ascorbic acid or a salt thereof, excluding ψ ψ1) ACTH in association with embonic acid or acorbic acid or a salt thereof and ψ2) a LHRH active compound in association with ascorbic acid or a salt thereof,ψ in a matrix of a polylactide, having a lactide / glycolide molar ratio of from 100:0 to 40:60, a Mw of from 10.000 to 200.000 and a polydispersity of from 1.7 to 3.0. ψψ