6640-50-2Relevant articles and documents
Cu nanoparticles embedded on reticular chitosan-derived N-doped carbon: Application to the catalytic hydrogenation of alkenes, alkynes and N-heteroarenes
Chen, Shuo,El Kadib, Abdelkrim,Hammi, Nisrine,Michon, Christophe,Royer, Sebastien
, (2022/01/20)
Applying biomass-waste as catalysts and catalytic supports is gaining a tremendous interest owing to its expected outcomes in terms of cost effectiveness and sustainability. In this context, we herein disclose a straightforward encapsulation of nanosized copper on hierarchically porous, biomass-derived nitrogen-containing carbon framework. Our approach uses chitosan - derived from the marine shell-fish wastes - as a cheap, sustainable carbon and nitrogen source, melamine as nitrogen provider and ethylenediaminetetraacetic acid as a cross-linker to induce the reticular network, much suitable for restricting the growth of the metal seeds. The resulting copper grown on nitrogen-doped carbon, bearing relatively large surface area (106 m2·g?1) and a large group of well-dispersed Cu nanoparticles (average of 2 nm) even with high Cu loading (41 wt%), exhibits catalytic activity for the hydrogenation of unsaturated double and triple carbon-carbon bonds and heteroaryles. This sustainable design of catalyst, using affordable copper and cheap biowaste, could discard palladium and other expensive elements loaded on tedious synthetic supports from the library of heterogeneous solids intended for fine chemical synthesis.
Identification and synthesis of DDI-6, a quinolinol analog capable of activating both caenorhabditis elegans and mouse spermatozoa
Karuo, Yukiko,Shiraki, Riona,Yoshida, Ayaka,Tsunokawa, Ryo,Nakahara-Yamada, Mayuko,Tarui, Atsushi,Sato, Kazuyuki,Kawai, Kentaro,Omote, Masaaki,Nishimura, Hitoshi
, p. 557 - 563 (2021/06/06)
Sperm activation is an essential process by which the male gametes become capable of fertilization. Because the process in Caenorhabditis elegans is readily reproducible in vitro, this organism serves as an excellent model to investigate it. C. elegans sperm activation in vivo occurs during spermiogenesis. Membranous organelles (MOs) contained within spermatids fuse with the plasma membrane, resulting in extracellular release of their contents and relocation of some proteins indispensable for fertilization from the MO membrane onto the sperm surface. Intriguingly, these cytological alternations are exhibited similarly in mouse spermatozoa during the acrosome reaction, which also represents a form of sperm activation, prompting us to hypothesize that C. elegans and mice share a common mechanism for sperm activation. To explore this, we first screened a chemical library to identify compounds that activate C. elegans spermatozoa. Because a quinolinol analog named DDI-6 seemed to be a candidate sperm activator, we synthesized it to use for further analyses. This involved direct dechlorination and hydrogenolysis of commercially available 5-chloro-8-quinolinol, both of which are key steps to yield 1,2,3,4-tetrahydro-8-quinolinol, and we subsequently introduced the sulfonamide group to the compound. When C. elegans spermatids were stimulated with solvent alone or the newly synthesized DDI-6, approx. 3% and approx. 28% of spermatids became MO-fused spermatozoa, respectively. Moreover, DDI-6 triggered the acrosome reaction in approx. 20% of mouse spermatozoa, while approx. 12% became acrosome-reacted after mock stimulation. Thus, DDI-6 serves as a moderately effective activator for both C. elegans and mouse spermatozoa.
Encapsulating Cobalt into N-Doping Hollow Frameworks for Efficient Cascade Catalysis
Yun, Ruirui,Zhang, Beibei,Qiu, Chuang,Ma, Ziwei,Zhan, Feiyang,Sheng, Tian,Zheng, Baishu
supporting information, p. 9757 - 9761 (2021/06/30)
The development of nonprecious catalysts for hydrogenation of organic molecules is of great importance in heterogeneous catalysis. Herein, we report a series of N-doped hollow carbon frameworks encompassing cobalt nanoparticles (denoted as Co@NHF-900) constructed as a new kind of reusable catalyst for this purpose by pyrolysis of ZIF-8@Co-dopamine under Ar atmospheres. Notably, the framework of ZIF-8 is essential for efficient catalyst by providing a carbon framework to support Co-dopamine. The experimental results reveal that the ZIF-8 renders a large hollow place within the catalysts, allowing the enrichment of the substrate and windows of the hollow structure and the ease of mass transfer of products during the reaction. All of the virtues made Co@NHF-900 a good candidate for hydrogenation of quinolines with high activity (TOF value of 119 h-1, which is several times than that of akin catalysts) and chemoselectivity.
