77771-22-3 Usage
Chemical structure
TPHQ has a quinoline structure with a pyridylcarbonyl functional group attached to it.
Synthetic compound
TPHQ is a synthetic compound, meaning it is not found naturally and is created through chemical synthesis.
Pharmaceutical and biological applications
TPHQ has been studied for its potential use in the pharmaceutical and biological fields.
Inhibitor of bacterial DNA gyrase and topoisomerase IV
TPHQ has shown promise as an inhibitor of these enzymes, which are involved in DNA replication and repair.
Potential anti-malarial drug
TPHQ has been found to inhibit the growth of Plasmodium falciparum, the parasite responsible for malaria.
Treatment of neurodegenerative diseases
TPHQ has been investigated for its potential use in treating neurodegenerative diseases due to its demonstrated neuroprotective effects in certain experimental models.
Versatile compound
TPHQ has potential applications in both pharmaceutical and biological research, making it a versatile compound for further study and development.
Check Digit Verification of cas no
The CAS Registry Mumber 77771-22-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,7,7 and 1 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 77771-22:
(7*7)+(6*7)+(5*7)+(4*7)+(3*1)+(2*2)+(1*2)=163
163 % 10 = 3
So 77771-22-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H14N2O2/c18-13-7-1-4-11-6-3-9-17(14(11)13)15(19)12-5-2-8-16-10-12/h1-2,4-5,7-8,10,18H,3,6,9H2
77771-22-3Relevant academic research and scientific papers
Adhikari, Priyanka,Bhattacharyya, Dipanjan,Das, Animesh,Konwar, Monuranjan,Nandi, Sekhar,Sarmah, Bikash Kumar
, p. 1214 - 1220 (2020)
Boric acid promoted transfer hydrogenation of substituted quinolines to synthetically versatile 1,2,3,4-tetrahydroquinolines (1,2,3,4-THQs) was described under mild reaction conditions using a Hantzsch ester as a mild organic hydrogen source. This methodology is practical and efficient, where isolated yields are excellent and reducible functional groups are well tolerated in the N-heteroarene moiety. The reaction parameters and tentative mechanistic pathways are demonstrated by various control experiments and NMR studies. The present work can also be scaled up to obtain gram quantities and the utility of the developed process is illustrated by the transformation of 1,2,3,4-THQs into a series of biologically important molecules including the antiarrhythmic drug nicainoprol.
