6640-54-6

Usage

Structure

sulfide derivative of benzene
The compound is derived from benzene by replacing one hydrogen atom with a sulfide group (S) and attaching a methyl group (CH3) at the 1 position and a nitrophenyl group (-C6H4NO2) at the 2 position.

Aromatic compound

presence of nitro group
The presence of the nitro group in the molecule contributes to its aromatic nature, which is a characteristic of many organic compounds with a stable ring structure.

Usage

organic synthesis and pharmaceutical research
1-methyl-2-[(2-nitrophenyl)sulfanyl]benzene is commonly used as a building block in organic synthesis and pharmaceutical research for the synthesis of other organic compounds.

Potential applications

new drugs or materials
Due to its unique molecular structure, this chemical may have potential applications in the development of new drugs or materials.

Safety concerns

health and environmental hazards
It is important to handle 1-methyl-2-[(2-nitrophenyl)sulfanyl]benzene with care, as it may pose health and environmental hazards if mishandled or improperly disposed of.

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 137-06-4 2-thiocresol 
• 552-16-9 ortho-nitrobenzoic acid 
• 5455-59-4 2-Nitrobenzenesulfonamide 

Downstream Products

• 61174-13-8 1-methyl-2-((2-nitrophenyl)sulfonyl)benzene 
• 93913-99-6 (2-aminophenyl)-2’-methylphenyl sulfide 
• 61174-28-5 2-Aminophenyl-2-tolylsulfon 
• 61174-43-4 2-Azidophenyl-2-tolylsulfon 

Relevant academic research and scientific papers

Primary sulfonamide as a coupling partner: Copper(I)-catalyzed regioselective cross-coupling of 2-nitro benzenesulfonamides with thiol through the cleavage of Ar–SO2NH2 bonds

In this article, we have presented a novel and efficient method for the direct synthesis of unsymmetrical sulfides through the copper(I)-catalyzed cross-coupling of 2-nitro benzenesulfonamides with thiols in the presence of catalytic amount of CuI in DMF as solvent at 100 °C. In addition, the products were obtained in high to excellent yields. More importantly, the novel system showed the primary 2-nitro benzenesulfonamides as a new coupling partner and regioselectively promoted C–S bond-forming transformations through the cleavage of Ar–SO2NH2 bonds.

Aerobic copper-catalyzed decarboxylative thiolation

Copper-catalyzed decarboxylative thiolation using molecular oxygen as the sole oxidant was developed. A variety of aromatic carboxylic acids including 2-nitrobenzoic acids, pentafluorobenzoic acid and several heteroaromatic carboxylic acids undergo efficient thiolation to furnish the aryl sulfides in moderate to excellent yields.

Conformational investigation of diarylsulphones by Kerr effect and dipole moment methods

Molar Kerr constants and electric dipole moments are reported for (C6H5)2SO2, (4Cl-C6H4)(C6H5)SO2, (2,4,6-Me3C6H2)(4'-Br-C6H4)SO2, (4-NO2C6H4)2SO2, (4-MeOC6H4)(4'-NO2C6H4)SO2, (2-MeOC6H4)(4'-NO2C6H4)SO2, (2-NO2C6H4)(4'-MeOC6H4)SO2 and (2-MeOC6H4)(2'-NO2C6H4)SO2 as solutes in dioxane solution at 298 K.The data are analysed in terms of the preferred conformations adopted in solution.In most cases these data are consistent with the presence, in dioxane, of orthogonal or planar-orthogonal conformers, or of a mixture of them.In the orthogonal rotamer both aromatic rings are approximately perpendicular to the CAr-S-CAr molecular reference plane whereas in the planar-orthogonal conformer one ring is coplanar and the other is orthogonal to the reference CAr-S-CAr plane.