66400-16-6Relevant articles and documents
Preparation method of alogliptin impurity
-
Paragraph 0072-0084, (2020/07/02)
The invention discloses a preparation method of an alogliptin impurity, which comprises the following steps: (1) reacting a cheap and accessible compound A as a raw material with benzyl halide to generate an intermediate B; (2) reacting the intermediate B with sodium methoxide to generate an intermediate C; (3) catalyzing the intermediate C to remove benzyl by Pd/C under the action of hydrogen toobtain an intermediate D; (4) carrying out nucleophilic substitution reaction on the intermediate D and the intermediate B to generate an intermediate E; (5) simultaneously removing benzyl and methylin the structure of the intermediate E under the action of acid to generate an intermediate F; and (6) reacting the intermediate F with a chlorinating agent, and chlorinating hydroxyl in the structureto generate the intermediate F. The preparation method provided by the invention has the advantages of cheap and easily available reaction raw materials, high yield, high purity and the like, and provides reliable material guarantee for subsequent quality control research and safety property research in the preparation process of the alogliptin.
