66422-02-4

Basic information

• Product Name: 4-methylbenzenesulfonic acid; 10-[3-[4-(2-pyridin-1-ylethyl)piperazin-1-yl]propyl]-2-(trifluoromethyl)phenothiazine
• CAS NO: 66422-02-4
• Molecular Formula: C₃₄H₃₈F₃N₄O₃S₂+
• Molecular Weight: 670.82
• Mol File: 66422-02-4.mol

Chemical Properties

• CAS DataBase Reference: 4-methylbenzenesulfonic acid; 10-[3-[4-(2-pyridin-1-ylethyl)piperazin-1-yl]propyl]-2-(trifluoromethyl)phenothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylbenzenesulfonic acid; 10-[3-[4-(2-pyridin-1-ylethyl)piperazin-1-yl]propyl]-2-(trifluoromethyl)phenothiazine(66422-02-4)
• EPA Substance Registry System: 4-methylbenzenesulfonic acid; 10-[3-[4-(2-pyridin-1-ylethyl)piperazin-1-yl]propyl]-2-(trifluoromethyl)phenothiazine(66422-02-4)

Safety Data

• Hazardous Substances Data: 66422-02-4(Hazardous Substances Data)

Upstream product

• 92-30-8 2-(trifluoromethyl)-10H-phenothiazine 
• 1675-46-3 10-(3-chloropropyl)-2-trifluoromethylphenothiazine 
• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 110-86-1 pyridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 69-23-8 Fluphenazine 

Relevant articles and documents

Potential CNS antitumor agents - Phenothiazines. II: Fluphenazine analogs

Fluphenazine was found to possess moderate, reproducible activity against the intraperitoneal L-1210 and P-388 leukemia murine tumor models. Seven ether derivatives of fluphenazine and eight compounds in which the terminal side-chain hydroxyl group was replaced by an amine function were prepared and evaluated in the intraperitoneal L-1210, P-388, and B16 melanoma systems as well as the intracerebral L-1210 and ependymoblastoma brain tumor models. While no substantial intracerebral activity was observed, seven derivatives possessed reproducible activity in the intraperitoneal L-1210 or P-388 system. Several gave T/C [(treated survival/control survival) x 100%] values of 150%. No B16 melanoma activity was observed. These compounds were also tested for their cytototoxic properties in culture against L-1210, P-388, and KB cells. The amine isosteres, while possessing little in vivo activity, were the most cytotoxic of the compounds prepared, with several having ED50 values 1 μg/ml.