66424-93-9

Upstream product

• 141-52-6 sodium ethanolate 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 612-23-7 2-nitrobenzyl chloride 
• 88-72-2 1-methyl-2-nitrobenzene 
• 64-17-5 ethanol 
• 88356-11-0 o-nitrobenzaldehyde diethylacetal 

Downstream Products

• 80171-91-1 2-ethoxymethyl-aniline 
• 20920-83-6 (ethoxymethyl)2-phenol 

Relevant academic research and scientific papers

Preparation method of benzyl bromide compound

The invention relates to a method for producing a benzyl bromide compound (I or II). The method has high reaction yield, high product purity, fewer produced three wastes and good environmental compatibility. The method has remarkable economic benefit, social benefit and environmental benefit. The formula is shown in the description.

trans-2,2′-dinitrostilbene as a precursor of 0-nitrobenzaldehyde, a key intermediate for pharmaceuticals: Reactivity and molecular structure studies

A novel synthesis of o-nitrobenzaldehyde by means of the ozonolysis-reductive hydrolysis of symmetrical trans-2,2′-dinitrostilbene is reported, yielding only the ortho isomer of nitrobenzaldehyde. This new route reduces environmental hazards in the synthesis of o-mtrobenzaldehyde. The central ethylene bond of trans-2,2′-dinitrostilbene showed a high reactivity for the ozonolysis reaction. The molecular structures of 2-nitrobenzaldehyde and trans-2,2′-dinitrostilbene were studied theoretically by means of ab initio quantum mechanical calculations at the 6-31G*//6-31G* level. A non-coplanar conformer was found for o-nitrobenzaldehyde, where the carbonyl and nitro groups are slightly twisted with respect to the phenyl ring. Also, a non-coplanar minimal s-trans-gauchels-transgauche conformer (NO2-aryl-C=C-aryl-NO2) was found for trans-2,2′-dinitrostilbene, where the aromatic groups are twisted with respect to the central double bond, and the nitro groups are also twisted out the planes of the aromatic rings. This structure is consistent with certain experimental physical-chemical properties of this molecule.

REARRANGEMENT OF SUBSTITUTED AROMATIC ACETALS CATALYSED BY γ-ALUMINA

Aromatic acetals over γ-alumina undergo rearrangement to give the corresponding esters (b) and ethers (c) in good yield.The product distribution varied unusually over the range of reaction temperatures.The effect of substituents has also been felt much in the study.Probable mechanisms have been suggested for the reaction.The catalyst has been characterized by various studies and the specific poisoning of the catalyst has been done with NH3, CO2 and H2S.