66427-83-6

Basic information

• Product Name: 2-chloro-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
• CAS NO: 66427-83-6
• Molecular Formula: C₁₁H₇ClN₄O
• Molecular Weight: 246.6525
• Mol File: 66427-83-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 412.7°C at 760 mmHg
• Flash Point: 203.4°C
• Density: 1.444g/cm³
• Vapor Pressure: 5.09E-07mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 2-chloro-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one(66427-83-6)
• EPA Substance Registry System: 2-chloro-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one(66427-83-6)

Safety Data

• Hazardous Substances Data: 66427-83-6(Hazardous Substances Data)

Upstream product

• 134-20-3 2-carbomethoxyaniline 

Relevant articles and documents

Synthesis and biological evaluation of BU-4664L derivatives as potential anticancer agents

BU-4664L is a naturally occurring N-farnesylated dibenzodiazepinone with important biological activities. Herein, we report the synthesis and antitumor evaluation of two series of BU-4664L derivatives bearing different substituent patterns on the dibenzodiazepinone core and with diverse side chains. All of the derivatives displayed micromolar activity against the human prostate cancer PC-3 cells, while lower or no activity against the human lung H460 cells. The most active derivatives were 10a and 16c which exerted antiproliferative activity against PC-3 cells with GI50 values of 5.66 and 5.94 μM, respectively, and thus represent promising lead compounds for further development.